Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A

In this opinion article, we discuss a serendipitous observation we made in a study investigating survival in aged mice after bacterial infection. This observation involved a non-invasive ventilation approach that led to variable and higher survival in male and female mice with different genetic back...

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Detalles Bibliográficos
Autores principales: Abbasi, Ata, Phelps, David S., Ravi, Radhika, Floros, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143458/
https://www.ncbi.nlm.nih.gov/pubmed/33922049
http://dx.doi.org/10.3390/antiox10050640
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author Abbasi, Ata
Phelps, David S.
Ravi, Radhika
Floros, Joanna
author_facet Abbasi, Ata
Phelps, David S.
Ravi, Radhika
Floros, Joanna
author_sort Abbasi, Ata
collection PubMed
description In this opinion article, we discuss a serendipitous observation we made in a study investigating survival in aged mice after bacterial infection. This observation involved a non-invasive ventilation approach that led to variable and higher survival in male and female mice with different genetic backgrounds for the innate immune molecule, surfactant protein A (SP-A). We suggest that employing the best ventilatory modality, whether that be HFNC or another method, may augment the role of other factors such as SP-A genetics and sex in a personalized approach, and may ultimately improve the outcome.
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spelling pubmed-81434582021-05-25 Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A Abbasi, Ata Phelps, David S. Ravi, Radhika Floros, Joanna Antioxidants (Basel) Opinion In this opinion article, we discuss a serendipitous observation we made in a study investigating survival in aged mice after bacterial infection. This observation involved a non-invasive ventilation approach that led to variable and higher survival in male and female mice with different genetic backgrounds for the innate immune molecule, surfactant protein A (SP-A). We suggest that employing the best ventilatory modality, whether that be HFNC or another method, may augment the role of other factors such as SP-A genetics and sex in a personalized approach, and may ultimately improve the outcome. MDPI 2021-04-22 /pmc/articles/PMC8143458/ /pubmed/33922049 http://dx.doi.org/10.3390/antiox10050640 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Abbasi, Ata
Phelps, David S.
Ravi, Radhika
Floros, Joanna
Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A
title Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A
title_full Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A
title_fullStr Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A
title_full_unstemmed Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A
title_short Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A
title_sort can prophylactic high flow of humidified and warmed filtered air improve survival from bacterial pneumonia and sars-cov-2 in elderly individuals? the role of surfactant protein a
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143458/
https://www.ncbi.nlm.nih.gov/pubmed/33922049
http://dx.doi.org/10.3390/antiox10050640
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