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Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics
Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers’ fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143628/ https://www.ncbi.nlm.nih.gov/pubmed/34104073 http://dx.doi.org/10.1080/15685551.2021.1929684 |
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author | Bi, Hongmei Chen, Zeqin Qiu, Jiaqin |
author_facet | Bi, Hongmei Chen, Zeqin Qiu, Jiaqin |
author_sort | Bi, Hongmei |
collection | PubMed |
description | Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers’ fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of two types of magnetic lipid microcapsules (MLMs) loading lipid-coated MNPs and uncoated MNPs respectively were compared deeply in experimental analysis and theoretical simulation. The simulation results revealed that almost same magnetic heat effect and temperature increasing exist between lipid-coated and uncoated MNPs, which was consistent with the experimental drug release results. Coating lipid on MNPs didn’t affect the magnetic heat and heat transfer of the MNPs. Because of the heat transfer between MNPs and water, MLMs and water around, the temperature increasing of whole sample solution is lower than that of the MNPs themselves. Our results provide a reliable theoretical basis for the development of healthy, safe, and biocompatible drug delivery systems. |
format | Online Article Text |
id | pubmed-8143628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-81436282021-06-07 Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics Bi, Hongmei Chen, Zeqin Qiu, Jiaqin Des Monomers Polym Short Communication Magnetic nanoparticles (MNPs) with safety, stability and excellent magneto-calorific effect are the precondition for the smart magnetic drug carriers’ fabrication and controllable drug release at a specific target in clinical treatment. In this study, the drug release and magneto-calorific effect of two types of magnetic lipid microcapsules (MLMs) loading lipid-coated MNPs and uncoated MNPs respectively were compared deeply in experimental analysis and theoretical simulation. The simulation results revealed that almost same magnetic heat effect and temperature increasing exist between lipid-coated and uncoated MNPs, which was consistent with the experimental drug release results. Coating lipid on MNPs didn’t affect the magnetic heat and heat transfer of the MNPs. Because of the heat transfer between MNPs and water, MLMs and water around, the temperature increasing of whole sample solution is lower than that of the MNPs themselves. Our results provide a reliable theoretical basis for the development of healthy, safe, and biocompatible drug delivery systems. Taylor & Francis 2021-05-18 /pmc/articles/PMC8143628/ /pubmed/34104073 http://dx.doi.org/10.1080/15685551.2021.1929684 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Bi, Hongmei Chen, Zeqin Qiu, Jiaqin Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics |
title | Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics |
title_full | Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics |
title_fullStr | Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics |
title_full_unstemmed | Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics |
title_short | Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics |
title_sort | drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143628/ https://www.ncbi.nlm.nih.gov/pubmed/34104073 http://dx.doi.org/10.1080/15685551.2021.1929684 |
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