Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease

Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay t...

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Detalles Bibliográficos
Autores principales: Karayel, Özge, Tonelli, Francesca, Virreira Winter, Sebastian, Geyer, Phillip E., Fan, Ying, Sammler, Esther M., Alessi, Dario R., Steger, Martin, Mann, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143643/
https://www.ncbi.nlm.nih.gov/pubmed/32601174
http://dx.doi.org/10.1074/mcp.RA120.002055

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