Anti-CD20 Depletes Meningeal B Cells but Does Not Halt the Formation of Meningeal Ectopic Lymphoid Tissue

OBJECTIVE: To investigate whether anti-CD20 B-cell-depleting monoclonal antibodies (ɑCD20 mAbs) inhibit the formation or retention of meningeal ectopic lymphoid tissue (mELT) in a murine model of multiple sclerosis (MS). METHODS: We used a spontaneous chronic experimental autoimmune encephalomyeliti...

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Detalles Bibliográficos
Autores principales: Brand, Rosa Margareta, Friedrich, Verena, Diddens, Jolien, Pfaller, Monika, Romana de Franchis, Francesca, Radbruch, Helena, Hemmer, Bernhard, Steiger, Katja, Lehmann-Horn, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143698/
https://www.ncbi.nlm.nih.gov/pubmed/34021057
http://dx.doi.org/10.1212/NXI.0000000000001012

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