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Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

Membrane fusion requires R-, Qa-, Qb-, and Qc-family SNAREs that zipper into RQaQbQc coiled coils, driven by the sequestration of apolar amino acids. Zippering has been thought to provide all the force driving fusion. Sec17/αSNAP can form an oligomeric assembly with SNAREs with the Sec17 C-terminus...

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Detalles Bibliográficos
Autores principales: Song, Hongki, Torng, Thomas L, Orr, Amy S, Brunger, Axel T, Wickner, William T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143792/
https://www.ncbi.nlm.nih.gov/pubmed/33944780
http://dx.doi.org/10.7554/eLife.67578