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The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature

While periodontitis has been proven to have an impact on systemic conditions, such as cardiovascular diseases, pregnancy complications, or poor glycemic control in diabetic patients, the influence of peri-implantitis on systemic health has not been adequately explored in the literature as yet. The e...

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Autores principales: Radaelli, Katherine, Alberti, Alice, Corbella, Stefano, Francetti, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143885/
https://www.ncbi.nlm.nih.gov/pubmed/34054959
http://dx.doi.org/10.1155/2021/5536566
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author Radaelli, Katherine
Alberti, Alice
Corbella, Stefano
Francetti, Luca
author_facet Radaelli, Katherine
Alberti, Alice
Corbella, Stefano
Francetti, Luca
author_sort Radaelli, Katherine
collection PubMed
description While periodontitis has been proven to have an impact on systemic conditions, such as cardiovascular diseases, pregnancy complications, or poor glycemic control in diabetic patients, the influence of peri-implantitis on systemic health has not been adequately explored in the literature as yet. The existing evidence suggests that peri-implant lesions lead to more intense inflammatory response than periodontitis. Given the analogies between periodontal diseases and peri-implantitis, the aim of the present paper was to review the scientific evidence about the potential correlation between peri-implantitis and systemic diseases and conditions. Two clinical trials on animals reported that experimental peri-implantitis determined an alteration in hematological and biological parameters. One human study explored the risk indicators for cardiovascular diseases and found that patients with peri-implantitis had significantly higher levels of triglyceride, uric acid, and white blood cells and lower levels of vitamin D. It was described in the literature that periodontitis affects cardiovascular health through a number of mechanisms, including the increase in systemic mediators of inflammation, which also has a role in the worsening of glycemic control in diabetic patients. Similarly, peri-implantitis may influence the systemic status through inflammatory cytokines such as IL-1, IL-6, and IL-10 and matrix metalloproteinases. One microbiological mechanism, based on the systemic dissemination of periodontal bacteria, has been hypothesized for cardiovascular diseases and pregnancy complications. Again, it is plausible that the same could occur in peri-implantitis. In conclusion, only few studies explored the systemic impact of peri-implantitis. Although changes in hematological parameters, biochemical parameters, and inflammatory markers have been reported in peri-implantitis, further studies are needed to investigate this correlation.
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spelling pubmed-81438852021-05-27 The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature Radaelli, Katherine Alberti, Alice Corbella, Stefano Francetti, Luca Int J Dent Review Article While periodontitis has been proven to have an impact on systemic conditions, such as cardiovascular diseases, pregnancy complications, or poor glycemic control in diabetic patients, the influence of peri-implantitis on systemic health has not been adequately explored in the literature as yet. The existing evidence suggests that peri-implant lesions lead to more intense inflammatory response than periodontitis. Given the analogies between periodontal diseases and peri-implantitis, the aim of the present paper was to review the scientific evidence about the potential correlation between peri-implantitis and systemic diseases and conditions. Two clinical trials on animals reported that experimental peri-implantitis determined an alteration in hematological and biological parameters. One human study explored the risk indicators for cardiovascular diseases and found that patients with peri-implantitis had significantly higher levels of triglyceride, uric acid, and white blood cells and lower levels of vitamin D. It was described in the literature that periodontitis affects cardiovascular health through a number of mechanisms, including the increase in systemic mediators of inflammation, which also has a role in the worsening of glycemic control in diabetic patients. Similarly, peri-implantitis may influence the systemic status through inflammatory cytokines such as IL-1, IL-6, and IL-10 and matrix metalloproteinases. One microbiological mechanism, based on the systemic dissemination of periodontal bacteria, has been hypothesized for cardiovascular diseases and pregnancy complications. Again, it is plausible that the same could occur in peri-implantitis. In conclusion, only few studies explored the systemic impact of peri-implantitis. Although changes in hematological parameters, biochemical parameters, and inflammatory markers have been reported in peri-implantitis, further studies are needed to investigate this correlation. Hindawi 2021-05-15 /pmc/articles/PMC8143885/ /pubmed/34054959 http://dx.doi.org/10.1155/2021/5536566 Text en Copyright © 2021 Katherine Radaelli et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Radaelli, Katherine
Alberti, Alice
Corbella, Stefano
Francetti, Luca
The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature
title The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature
title_full The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature
title_fullStr The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature
title_full_unstemmed The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature
title_short The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature
title_sort impact of peri-implantitis on systemic diseases and conditions: a review of the literature
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143885/
https://www.ncbi.nlm.nih.gov/pubmed/34054959
http://dx.doi.org/10.1155/2021/5536566
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