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COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients

PURPOSE: There is mounting evidence that surgical patients with COVID-19 have higher morbidity and mortality than patients without COVID-19. Infection is prevalent amongst the trauma population, but any effect of COVID-19 on trauma patients is unknown. We aimed to evaluate the effect of COVID-19 on...

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Autores principales: Yeates, Eric O., Grigorian, Areg, Schellenberg, Morgan, Owattanapanich, Natthida, Barmparas, Galinos, Margulies, Daniel, Juillard, Catherine, Garber, Kent, Cryer, Henry, Tillou, Areti, Burruss, Sigrid, Figueras, Ryan Arthur, Mladenov, Georgi, Brenner, Megan, Firek, Christopher, Costantini, Todd, Santorelli, Jarrett, Curry, Terry, Wintz, Diane, Biffl, Walter L., Schaffer, Kathryn B., Duncan, Thomas K., Barbaro, Casey, Diaz, Graal, Johnson, Arianne, Chinn, Justine, Naaseh, Ariana, Leung, Amanda, Grabar, Christina, Nahmias, Jeffry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143988/
https://www.ncbi.nlm.nih.gov/pubmed/34031703
http://dx.doi.org/10.1007/s00068-021-01699-9
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author Yeates, Eric O.
Grigorian, Areg
Schellenberg, Morgan
Owattanapanich, Natthida
Barmparas, Galinos
Margulies, Daniel
Juillard, Catherine
Garber, Kent
Cryer, Henry
Tillou, Areti
Burruss, Sigrid
Figueras, Ryan Arthur
Mladenov, Georgi
Brenner, Megan
Firek, Christopher
Costantini, Todd
Santorelli, Jarrett
Curry, Terry
Wintz, Diane
Biffl, Walter L.
Schaffer, Kathryn B.
Duncan, Thomas K.
Barbaro, Casey
Diaz, Graal
Johnson, Arianne
Chinn, Justine
Naaseh, Ariana
Leung, Amanda
Grabar, Christina
Nahmias, Jeffry
author_facet Yeates, Eric O.
Grigorian, Areg
Schellenberg, Morgan
Owattanapanich, Natthida
Barmparas, Galinos
Margulies, Daniel
Juillard, Catherine
Garber, Kent
Cryer, Henry
Tillou, Areti
Burruss, Sigrid
Figueras, Ryan Arthur
Mladenov, Georgi
Brenner, Megan
Firek, Christopher
Costantini, Todd
Santorelli, Jarrett
Curry, Terry
Wintz, Diane
Biffl, Walter L.
Schaffer, Kathryn B.
Duncan, Thomas K.
Barbaro, Casey
Diaz, Graal
Johnson, Arianne
Chinn, Justine
Naaseh, Ariana
Leung, Amanda
Grabar, Christina
Nahmias, Jeffry
author_sort Yeates, Eric O.
collection PubMed
description PURPOSE: There is mounting evidence that surgical patients with COVID-19 have higher morbidity and mortality than patients without COVID-19. Infection is prevalent amongst the trauma population, but any effect of COVID-19 on trauma patients is unknown. We aimed to evaluate the effect of COVID-19 on a trauma population, hypothesizing increased mortality and pulmonary complications for COVID-19-positive (COVID) trauma patients compared to propensity-matched COVID-19-negative (non-COVID) patients. METHODS: A retrospective analysis of trauma patients presenting to 11 Level-I and II trauma centers in California between 1/1/2019–6/30/2019 and 1/1/2020–6/30/2020 was performed. A 1:2 propensity score model was used to match COVID to non-COVID trauma patients using age, blunt/penetrating mechanism, injury severity score, Glasgow Coma Scale score, systolic blood pressure, respiratory rate, and heart rate. Outcomes were compared between the two groups. RESULTS: A total of 20,448 trauma patients were identified during the study period. 53 COVID trauma patients were matched with 106 non-COVID trauma patients. COVID patients had higher rates of mortality (9.4% vs 1.9%, p = 0.029) and pneumonia (7.5% vs. 0.0%, p = 0.011), as well as a longer mean length of stay (LOS) (7.47 vs 3.28 days, p < 0.001) and intensive care unit LOS (1.40 vs 0.80 days, p = 0.008), compared to non-COVID patients. CONCLUSION: This multicenter retrospective study found increased rates of mortality and pneumonia, as well as a longer LOS, for COVID trauma patients compared to a propensity-matched cohort of non-COVID patients. Further studies are warranted to validate these findings and to elucidate the underlying pathways responsible for higher mortality in COVID trauma patients.
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spelling pubmed-81439882021-05-25 COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients Yeates, Eric O. Grigorian, Areg Schellenberg, Morgan Owattanapanich, Natthida Barmparas, Galinos Margulies, Daniel Juillard, Catherine Garber, Kent Cryer, Henry Tillou, Areti Burruss, Sigrid Figueras, Ryan Arthur Mladenov, Georgi Brenner, Megan Firek, Christopher Costantini, Todd Santorelli, Jarrett Curry, Terry Wintz, Diane Biffl, Walter L. Schaffer, Kathryn B. Duncan, Thomas K. Barbaro, Casey Diaz, Graal Johnson, Arianne Chinn, Justine Naaseh, Ariana Leung, Amanda Grabar, Christina Nahmias, Jeffry Eur J Trauma Emerg Surg Original Article PURPOSE: There is mounting evidence that surgical patients with COVID-19 have higher morbidity and mortality than patients without COVID-19. Infection is prevalent amongst the trauma population, but any effect of COVID-19 on trauma patients is unknown. We aimed to evaluate the effect of COVID-19 on a trauma population, hypothesizing increased mortality and pulmonary complications for COVID-19-positive (COVID) trauma patients compared to propensity-matched COVID-19-negative (non-COVID) patients. METHODS: A retrospective analysis of trauma patients presenting to 11 Level-I and II trauma centers in California between 1/1/2019–6/30/2019 and 1/1/2020–6/30/2020 was performed. A 1:2 propensity score model was used to match COVID to non-COVID trauma patients using age, blunt/penetrating mechanism, injury severity score, Glasgow Coma Scale score, systolic blood pressure, respiratory rate, and heart rate. Outcomes were compared between the two groups. RESULTS: A total of 20,448 trauma patients were identified during the study period. 53 COVID trauma patients were matched with 106 non-COVID trauma patients. COVID patients had higher rates of mortality (9.4% vs 1.9%, p = 0.029) and pneumonia (7.5% vs. 0.0%, p = 0.011), as well as a longer mean length of stay (LOS) (7.47 vs 3.28 days, p < 0.001) and intensive care unit LOS (1.40 vs 0.80 days, p = 0.008), compared to non-COVID patients. CONCLUSION: This multicenter retrospective study found increased rates of mortality and pneumonia, as well as a longer LOS, for COVID trauma patients compared to a propensity-matched cohort of non-COVID patients. Further studies are warranted to validate these findings and to elucidate the underlying pathways responsible for higher mortality in COVID trauma patients. Springer Berlin Heidelberg 2021-05-25 2021 /pmc/articles/PMC8143988/ /pubmed/34031703 http://dx.doi.org/10.1007/s00068-021-01699-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Yeates, Eric O.
Grigorian, Areg
Schellenberg, Morgan
Owattanapanich, Natthida
Barmparas, Galinos
Margulies, Daniel
Juillard, Catherine
Garber, Kent
Cryer, Henry
Tillou, Areti
Burruss, Sigrid
Figueras, Ryan Arthur
Mladenov, Georgi
Brenner, Megan
Firek, Christopher
Costantini, Todd
Santorelli, Jarrett
Curry, Terry
Wintz, Diane
Biffl, Walter L.
Schaffer, Kathryn B.
Duncan, Thomas K.
Barbaro, Casey
Diaz, Graal
Johnson, Arianne
Chinn, Justine
Naaseh, Ariana
Leung, Amanda
Grabar, Christina
Nahmias, Jeffry
COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients
title COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients
title_full COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients
title_fullStr COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients
title_full_unstemmed COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients
title_short COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients
title_sort covid-19 in trauma: a propensity-matched analysis of covid and non-covid trauma patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143988/
https://www.ncbi.nlm.nih.gov/pubmed/34031703
http://dx.doi.org/10.1007/s00068-021-01699-9
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