Neurotrophic effects of Botulinum neurotoxin type A in hippocampal neurons involve activation of Rac1 by the non-catalytic heavy chain (HC(C)/A)

Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration in preclinical models. Here we report that the non...

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Detalles Bibliográficos
Autores principales: Solabre Valois, Luis, Shi, Vanilla (Hua), Bishop, Paul, Zhu, Bangfu, Nakamura, Yasuko, Wilkinson, Kevin A., Henley, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143998/
https://www.ncbi.nlm.nih.gov/pubmed/34041508
http://dx.doi.org/10.1016/j.ibneur.2021.04.002

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