Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic. Here, we show that mtDNA-dependent immune signalling via the cyclic GMP–AMP synthase‒stimulator of interferon genes‒TANK-binding kinase 1 (cGAS–ST...

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Detalles Bibliográficos
Autores principales: Sprenger, Hans-Georg, MacVicar, Thomas, Bahat, Amir, Fiedler, Kai Uwe, Hermans, Steffen, Ehrentraut, Denise, Ried, Katharina, Milenkovic, Dusanka, Bonekamp, Nina, Larsson, Nils-Göran, Nolte, Hendrik, Giavalisco, Patrick, Langer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144018/
https://www.ncbi.nlm.nih.gov/pubmed/33903774
http://dx.doi.org/10.1038/s42255-021-00385-9

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