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Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study
INTRODUCTION: South Africa (SA) has a high HIV prevalence and limited mental healthcare resources. Neuropsychiatric complications such as psychosis onset in people living with HIV (PLWHIV) remains poorly understood. The study aims to compare the socio-demographic, clinical, substance use, cognitive...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144045/ https://www.ncbi.nlm.nih.gov/pubmed/34020979 http://dx.doi.org/10.1136/bmjopen-2020-046593 |
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author | Chhagan, Usha Ntlantsana, Vuyokazi Tomita, Andrew Naidu, Thirusha Chiliza, Bonginkosi Paruk, Saeeda |
author_facet | Chhagan, Usha Ntlantsana, Vuyokazi Tomita, Andrew Naidu, Thirusha Chiliza, Bonginkosi Paruk, Saeeda |
author_sort | Chhagan, Usha |
collection | PubMed |
description | INTRODUCTION: South Africa (SA) has a high HIV prevalence and limited mental healthcare resources. Neuropsychiatric complications such as psychosis onset in people living with HIV (PLWHIV) remains poorly understood. The study aims to compare the socio-demographic, clinical, substance use, cognitive and trauma profile of PLWHIV presenting with first episode psychosis (FEP) to those with the condition but without HIV. METHODS AND ANALYSIS: This study will compare presentation, course, and outcome of a cohort of PLWHIV and FEP with a control group recruited over a 3-year period. We will prospectively test the hypothesis that the 2 groups are socio-demographically, clinically and cognitively distinct at illness presentation, with higher trauma burden and poorer outcomes in those with the dual burden of HIV and FEP. FEP participants, confirmed by a structured neuropsychiatric interview, will have their socio-demographic, psychosis, mood, motor, trauma and substance use variables assessed. A neuropsychological battery will be completed to assess cognition, while quality of life, psychotic symptoms and HIV markers will be measured at 3, 6 and 12 months. ETHICS AND DISSEMINATION: The study protocol has been reviewed and ethics approval obtained from the Biomedical Research Ethics Committee (BC 571/18) of the University of KwaZulu-Natal. The results from this investigation will be actively disseminated through peer-reviewed journal publications and conference presentations. |
format | Online Article Text |
id | pubmed-8144045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-81440452021-06-07 Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study Chhagan, Usha Ntlantsana, Vuyokazi Tomita, Andrew Naidu, Thirusha Chiliza, Bonginkosi Paruk, Saeeda BMJ Open Mental Health INTRODUCTION: South Africa (SA) has a high HIV prevalence and limited mental healthcare resources. Neuropsychiatric complications such as psychosis onset in people living with HIV (PLWHIV) remains poorly understood. The study aims to compare the socio-demographic, clinical, substance use, cognitive and trauma profile of PLWHIV presenting with first episode psychosis (FEP) to those with the condition but without HIV. METHODS AND ANALYSIS: This study will compare presentation, course, and outcome of a cohort of PLWHIV and FEP with a control group recruited over a 3-year period. We will prospectively test the hypothesis that the 2 groups are socio-demographically, clinically and cognitively distinct at illness presentation, with higher trauma burden and poorer outcomes in those with the dual burden of HIV and FEP. FEP participants, confirmed by a structured neuropsychiatric interview, will have their socio-demographic, psychosis, mood, motor, trauma and substance use variables assessed. A neuropsychological battery will be completed to assess cognition, while quality of life, psychotic symptoms and HIV markers will be measured at 3, 6 and 12 months. ETHICS AND DISSEMINATION: The study protocol has been reviewed and ethics approval obtained from the Biomedical Research Ethics Committee (BC 571/18) of the University of KwaZulu-Natal. The results from this investigation will be actively disseminated through peer-reviewed journal publications and conference presentations. BMJ Publishing Group 2021-05-21 /pmc/articles/PMC8144045/ /pubmed/34020979 http://dx.doi.org/10.1136/bmjopen-2020-046593 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Mental Health Chhagan, Usha Ntlantsana, Vuyokazi Tomita, Andrew Naidu, Thirusha Chiliza, Bonginkosi Paruk, Saeeda Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study |
title | Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study |
title_full | Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study |
title_fullStr | Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study |
title_full_unstemmed | Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study |
title_short | Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study |
title_sort | investigating the impact of hiv on patients with first episode psychosis: a study protocol for a longitudinal cohort study |
topic | Mental Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144045/ https://www.ncbi.nlm.nih.gov/pubmed/34020979 http://dx.doi.org/10.1136/bmjopen-2020-046593 |
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