Cargando…
Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review
Soil-transmitted helminths (Ascaris lumbricoides, hookworm and Trichuris trichiura) infect about one-fifth of the world’s population. The currently available drugs are all highly efficacious against A. lumbricoides. However, they are only moderately efficacious against hookworm and poorly efficaciou...
Autores principales: | Palmeirim, Marta S., Specht, Sabine, Scandale, Ivan, Gander-Meisterernst, Irene, Chabicovsky, Monika, Keiser, Jennifer |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144136/ https://www.ncbi.nlm.nih.gov/pubmed/33929716 http://dx.doi.org/10.1007/s40265-021-01505-1 |
Ejemplares similares
-
Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota
por: Schneeberger, Pierre H.H., et al.
Publicado: (2018) -
Activity of Oxantel Pamoate Monotherapy and Combination Chemotherapy against Trichuris muris and Hookworms: Revival of an Old Drug
por: Keiser, Jennifer, et al.
Publicado: (2013) -
Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole
por: Speich, Benjamin, et al.
Publicado: (2016) -
Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes
por: Cowan, Noemi, et al.
Publicado: (2017) -
Onchocerciasis drug development: from preclinical models to humans
por: Ngwewondo, Adela, et al.
Publicado: (2021)