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Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection
COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic optio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144203/ https://www.ncbi.nlm.nih.gov/pubmed/34031419 http://dx.doi.org/10.1038/s41540-021-00181-x |
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author | Salgado-Albarrán, Marisol Navarro-Delgado, Erick I. Del Moral-Morales, Aylin Alcaraz, Nicolas Baumbach, Jan González-Barrios, Rodrigo Soto-Reyes, Ernesto |
author_facet | Salgado-Albarrán, Marisol Navarro-Delgado, Erick I. Del Moral-Morales, Aylin Alcaraz, Nicolas Baumbach, Jan González-Barrios, Rodrigo Soto-Reyes, Ernesto |
author_sort | Salgado-Albarrán, Marisol |
collection | PubMed |
description | COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic options. Transcriptional changes due to epigenetic regulation are key host cell responses to viral infection and have been studied in SARS-CoV and MERS-CoV; however, such changes are not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes obtained from cell lines infected with MERS-CoV, SARS-CoV, and SARS-CoV-2, and from COVID-19 patient-derived samples. Using integrative analyses of gene co-expression networks and de-novo pathway enrichment, we characterize different gene modules and protein pathways enriched with Transcription Factors or Epifactors relevant for SARS-CoV-2 infection. We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential. Our results show that targeting the epigenetic machinery could be a feasible alternative to treat COVID-19. |
format | Online Article Text |
id | pubmed-8144203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81442032021-06-07 Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection Salgado-Albarrán, Marisol Navarro-Delgado, Erick I. Del Moral-Morales, Aylin Alcaraz, Nicolas Baumbach, Jan González-Barrios, Rodrigo Soto-Reyes, Ernesto NPJ Syst Biol Appl Article COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic options. Transcriptional changes due to epigenetic regulation are key host cell responses to viral infection and have been studied in SARS-CoV and MERS-CoV; however, such changes are not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes obtained from cell lines infected with MERS-CoV, SARS-CoV, and SARS-CoV-2, and from COVID-19 patient-derived samples. Using integrative analyses of gene co-expression networks and de-novo pathway enrichment, we characterize different gene modules and protein pathways enriched with Transcription Factors or Epifactors relevant for SARS-CoV-2 infection. We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential. Our results show that targeting the epigenetic machinery could be a feasible alternative to treat COVID-19. Nature Publishing Group UK 2021-05-24 /pmc/articles/PMC8144203/ /pubmed/34031419 http://dx.doi.org/10.1038/s41540-021-00181-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Salgado-Albarrán, Marisol Navarro-Delgado, Erick I. Del Moral-Morales, Aylin Alcaraz, Nicolas Baumbach, Jan González-Barrios, Rodrigo Soto-Reyes, Ernesto Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection |
title | Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection |
title_full | Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection |
title_fullStr | Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection |
title_full_unstemmed | Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection |
title_short | Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection |
title_sort | comparative transcriptome analysis reveals key epigenetic targets in sars-cov-2 infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144203/ https://www.ncbi.nlm.nih.gov/pubmed/34031419 http://dx.doi.org/10.1038/s41540-021-00181-x |
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