Cargando…

Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization

Human intestinal peptide transporter PEPT1 is commonly repressed in human colorectal cancer (CRC), yet its relationship with sensitivity to the common CRC treatment ubenimex has not previously been elucidated. In this study, we confirmed PEPT1 suppression in CRC using real-time quantitative polymera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yanhong, Wang, Jiaqi, Yang, Lingrong, Qiu, Liqing, Hua, Yuhui, Wu, Shixiu, Zeng, Su, Yu, Lushan, Zheng, Xiaoli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144210/ https://www.ncbi.nlm.nih.gov/pubmed/34031358 http://dx.doi.org/10.1038/s41419-021-03814-5

Ejemplares similares

USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2
por: Warsi, Jamshed, et al.
Publicado: (2015)

Regulation profile of the intestinal peptide transporter 1 (PepT1)
por: Wang, Chun-Yang, et al.
Publicado: (2017)

Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1
por: Foley, David, et al.
Publicado: (2009)

Development and Characterization of a Novel Mouse Line Humanized for the Intestinal Peptide Transporter PEPT1
por: Hu, Yongjun, et al.
Publicado: (2014)

How the Intestinal Peptide Transporter PEPT-1 Contributes to an Obesity Phenotype in Caenorhabditits elegans
por: Spanier, Britta, et al.
Publicado: (2009)

Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
por: Stauffer, Mirko, et al.
Publicado: (2022)

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport
por: Beale, John H., et al.
Publicado: (2015)

Butyrate Transcriptionally Enhances Peptide Transporter PepT1 Expression and Activity
por: Dalmasso, Guillaume, et al.
Publicado: (2008)

Structural basis for oligomerization of the prokaryotic peptide transporter PepT(So2)
por: Nagamura, Reina, et al.
Publicado: (2019)

Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters
por: Khavinson, Vladimir Khatskelevich, et al.
Publicado: (2023)

The Intestinal Peptide Transporter PEPT1 Is Involved in Food Intake Regulation in Mice Fed a High-Protein Diet
por: Nässl, Anna-Maria, et al.
Publicado: (2011)

The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter–channel fence?
por: Meredith, David
Publicado: (2008)

The teleost fish PepT1-type peptide transporters and their relationships with neutral and charged substrates
por: Vacca, Francesca, et al.
Publicado: (2023)

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
por: Killer, Maxime, et al.
Publicado: (2021)

The Reproduction Rate of Peptide Transporter PEPT-1 Deficient C. elegans Is Dependent on Dietary Glutamate Supply
por: Spanier, Britta, et al.
Publicado: (2018)

Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1
por: Pieri, Myrtani, et al.
Publicado: (2008)

A Glutathione Peroxidase, Intracellular Peptidases and the TOR Complexes Regulate Peptide Transporter PEPT-1 in C. elegans
por: Benner, Jacqueline, et al.
Publicado: (2011)

Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals
por: Parker, Joanne L., et al.
Publicado: (2021)

PeptX: Using Genetic Algorithms to optimize peptides for MHC binding
por: Knapp, Bernhard, et al.
Publicado: (2011)

Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1
por: Søndergaard, Helle Bach, et al.
Publicado: (2012)

Tenapanor administration and the activity of the H(+)‐coupled transporter PepT1 in healthy volunteers
por: Johansson, Susanne, et al.
Publicado: (2017)

Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
por: Vacca, Francesca, et al.
Publicado: (2022)

CycPeptMPDB: A Comprehensive Database of Membrane Permeability of Cyclic Peptides
por: Li, Jianan, et al.
Publicado: (2023)

AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
por: Zeng, Wen-Feng, et al.
Publicado: (2022)

Standard method for performing positron emission particle tracking (PEPT) measurements of froth flotation at PEPT Cape Town
por: Cole, Katie, et al.
Publicado: (2022)

Effects of Short-Term Fasting on mRNA Expression of Ghrelin and the Peptide Transporters PepT1 and 2 in Atlantic Salmon (Salmo salar)
por: Del Vecchio, Gianmarco, et al.
Publicado: (2021)

Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs)
por: Luo, Yining, et al.
Publicado: (2023)

Evaluation of PepT1 (SLC15A1) Substrate Characteristics of Therapeutic Cyclic Peptides
por: Bajraktari-Sylejmani, Gzona, et al.
Publicado: (2022)

Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
por: Dranse, Helen J., et al.
Publicado: (2018)

JAK2 Mediates the Regulation of Pept1 Expression by Leptin in the Grass Carp (Ctenopharyngodon idella) Intestine
por: Luo, Wen-jie, et al.
Publicado: (2020)

Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model
por: Viennois, Emilie, et al.
Publicado: (2016)

pyPept: a python library to generate atomistic 2D and 3D representations of peptides
por: Ochoa, Rodrigo, et al.
Publicado: (2023)

The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1
por: Pieri, Myrtani, et al.
Publicado: (2009)

Rapid and Sensitive Quantification of Intracellular Glycyl-Sarcosine for Semi-High-Throughput Screening for Inhibitors of PEPT-1
por: von Linde, Teresa, et al.
Publicado: (2021)

Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters
por: Tsume, Yasuhiro, et al.
Publicado: (2008)

PEPT1-mediated prodrug strategy for oral delivery of peramivir
por: Sun, Yongbing, et al.
Publicado: (2018)

Structure determination of a major facilitator peptide transporter: Inward facing PepT(St) from Streptococcus thermophilus crystallized in space group P3(1)21
por: Quistgaard, Esben M., et al.
Publicado: (2017)

PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis
por: Zhang, Yuchen, et al.
Publicado: (2016)

Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations
por: Viennois, Emilie, et al.
Publicado: (2020)

Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship
por: Wu, Guiqin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_seea8pj8qg1i4km50amulvm8gp