Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development

De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). In mouse, constitutive Cul3 haploinsufficiency leads to motor coordination deficits as well as ASD-relevant social and cognitive impairments. However, induction of Cul3 hap...

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Detalles Bibliográficos
Autores principales: Morandell, Jasmin, Schwarz, Lena A., Basilico, Bernadette, Tasciyan, Saren, Dimchev, Georgi, Nicolas, Armel, Sommer, Christoph, Kreuzinger, Caroline, Dotter, Christoph P., Knaus, Lisa S., Dobler, Zoe, Cacci, Emanuele, Schur, Florian K. M., Danzl, Johann G., Novarino, Gaia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144225/
https://www.ncbi.nlm.nih.gov/pubmed/34031387
http://dx.doi.org/10.1038/s41467-021-23123-x

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