Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer’s Disease: A Targeted Transcriptome Analysis

Brain myeloid cells, include infiltrating macrophages and resident microglia, play an essential role in responding to and inducing neurodegenerative diseases, such as Alzheimer’s disease (AD). Genome-wide association studies (GWAS) implicate many AD casual and risk genes enriched in brain myeloid ce...

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Detalles Bibliográficos
Autores principales: Ma, Chao, Hunt, Jerry B., Kovalenko, Andrii, Liang, Huimin, Selenica, Maj-Linda B., Orr, Michael B., Zhang, Bei, Gensel, John C., Feola, David J., Gordon, Marcia N., Morgan, Dave, Bickford, Paula C., Lee, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144303/
https://www.ncbi.nlm.nih.gov/pubmed/34046031
http://dx.doi.org/10.3389/fimmu.2021.628156

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