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Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder

PURPOSE: To report a case of recurrent iris post-transplant lymphoproliferative disorder (PTLD) treated with ultra-low-dose (boom-boom) radiotherapy (RT). OBSERVATIONS: A 12-year-old Caucasian male with a history of bilateral, recurrent iris PTLD of the extranodal marginal zone lymphoma (MALT) type...

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Autores principales: Astafurov, Konstantin V., Bothun, Erick D., Laack, Nadia N., Deisher, Amanda J., Patel, Sanjay V., Dalvin, Lauren A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144319/
https://www.ncbi.nlm.nih.gov/pubmed/34041417
http://dx.doi.org/10.1016/j.ajoc.2021.101118
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author Astafurov, Konstantin V.
Bothun, Erick D.
Laack, Nadia N.
Deisher, Amanda J.
Patel, Sanjay V.
Dalvin, Lauren A.
author_facet Astafurov, Konstantin V.
Bothun, Erick D.
Laack, Nadia N.
Deisher, Amanda J.
Patel, Sanjay V.
Dalvin, Lauren A.
author_sort Astafurov, Konstantin V.
collection PubMed
description PURPOSE: To report a case of recurrent iris post-transplant lymphoproliferative disorder (PTLD) treated with ultra-low-dose (boom-boom) radiotherapy (RT). OBSERVATIONS: A 12-year-old Caucasian male with a history of bilateral, recurrent iris PTLD of the extranodal marginal zone lymphoma (MALT) type presented with persistent bilateral anterior chamber cellular infiltration, which was incompletely controlled on topical corticosteroids, and with elevated intraocular pressure (IOP) in the right eye secondary to steroid response. The patient was diagnosed with PTLD recurrence and was successfully treated with ultra-low-dose RT to both eyes in 2 fractions of 2 Gy. At 15 month follow-up the patient maintained complete disease control with normal IOP off all topical ophthalmic medications. CONCLUSIONS AND IMPORTANCE: Ultra-low-dose RT for ocular PTLD of the MALT subtype represents a novel therapeutic approach that may provide a durable treatment response and could be considered as either primary or adjuvant therapy for this rare condition.
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spelling pubmed-81443192021-05-25 Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder Astafurov, Konstantin V. Bothun, Erick D. Laack, Nadia N. Deisher, Amanda J. Patel, Sanjay V. Dalvin, Lauren A. Am J Ophthalmol Case Rep Case Report PURPOSE: To report a case of recurrent iris post-transplant lymphoproliferative disorder (PTLD) treated with ultra-low-dose (boom-boom) radiotherapy (RT). OBSERVATIONS: A 12-year-old Caucasian male with a history of bilateral, recurrent iris PTLD of the extranodal marginal zone lymphoma (MALT) type presented with persistent bilateral anterior chamber cellular infiltration, which was incompletely controlled on topical corticosteroids, and with elevated intraocular pressure (IOP) in the right eye secondary to steroid response. The patient was diagnosed with PTLD recurrence and was successfully treated with ultra-low-dose RT to both eyes in 2 fractions of 2 Gy. At 15 month follow-up the patient maintained complete disease control with normal IOP off all topical ophthalmic medications. CONCLUSIONS AND IMPORTANCE: Ultra-low-dose RT for ocular PTLD of the MALT subtype represents a novel therapeutic approach that may provide a durable treatment response and could be considered as either primary or adjuvant therapy for this rare condition. Elsevier 2021-05-15 /pmc/articles/PMC8144319/ /pubmed/34041417 http://dx.doi.org/10.1016/j.ajoc.2021.101118 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Astafurov, Konstantin V.
Bothun, Erick D.
Laack, Nadia N.
Deisher, Amanda J.
Patel, Sanjay V.
Dalvin, Lauren A.
Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder
title Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder
title_full Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder
title_fullStr Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder
title_full_unstemmed Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder
title_short Ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder
title_sort ultra-low-dose (boom-boom) radiotherapy for management of recurrent ocular post-transplant lymphoproliferative disorder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144319/
https://www.ncbi.nlm.nih.gov/pubmed/34041417
http://dx.doi.org/10.1016/j.ajoc.2021.101118
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