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Reward-related neural correlates of early life stress in school-aged children

OBJECTIVES: Early life stress likely contributes to dysfunction in neural reward processing systems. However, studies to date have focused almost exclusively on adolescents and adults, measured early life stress retrospectively, and have often failed to control for concurrent levels of stress. The c...

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Autores principales: Morelli, Nicholas M., Liuzzi, Michael T., Duong, Jacqueline B., Kryza-Lacombe, Maria, Chad-Friedman, Emma, Villodas, Miguel T., Dougherty, Lea R., Wiggins, Jillian Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144345/
https://www.ncbi.nlm.nih.gov/pubmed/34020397
http://dx.doi.org/10.1016/j.dcn.2021.100963
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author Morelli, Nicholas M.
Liuzzi, Michael T.
Duong, Jacqueline B.
Kryza-Lacombe, Maria
Chad-Friedman, Emma
Villodas, Miguel T.
Dougherty, Lea R.
Wiggins, Jillian Lee
author_facet Morelli, Nicholas M.
Liuzzi, Michael T.
Duong, Jacqueline B.
Kryza-Lacombe, Maria
Chad-Friedman, Emma
Villodas, Miguel T.
Dougherty, Lea R.
Wiggins, Jillian Lee
author_sort Morelli, Nicholas M.
collection PubMed
description OBJECTIVES: Early life stress likely contributes to dysfunction in neural reward processing systems. However, studies to date have focused almost exclusively on adolescents and adults, measured early life stress retrospectively, and have often failed to control for concurrent levels of stress. The current study examined the contribution of prospectively measured cumulative life stress in preschool-age children on reward-related neural activation and connectivity in school-age children. METHODS: Children (N = 46) and caregivers reported children’s exposure to early life stress between birth and preschool age (mean = 4.8 years, SD = 0.80). At follow-up (mean age = 7.52 years, SD = .78), participants performed a child-friendly monetary incentive delay task during functional magnetic resonance imaging. RESULTS: Children with higher levels of cumulative early life stress, controlling for concurrent stressful life events, exhibited aberrant patterns of neural activation and connectivity in reward- and emotion-related regions (e.g., prefrontal cortex, temporal pole, culmen), depending on the presence of a potential reward and whether or not the target was hit or missed. CONCLUSIONS: Findings suggest that stress exposure during early childhood may impact neural reward processing systems earlier in development than has previously been demonstrated. Understanding how early life stress relates to alterations in reward processing could guide earlier, more mechanistic interventions.
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spelling pubmed-81443452021-05-25 Reward-related neural correlates of early life stress in school-aged children Morelli, Nicholas M. Liuzzi, Michael T. Duong, Jacqueline B. Kryza-Lacombe, Maria Chad-Friedman, Emma Villodas, Miguel T. Dougherty, Lea R. Wiggins, Jillian Lee Dev Cogn Neurosci Original Research OBJECTIVES: Early life stress likely contributes to dysfunction in neural reward processing systems. However, studies to date have focused almost exclusively on adolescents and adults, measured early life stress retrospectively, and have often failed to control for concurrent levels of stress. The current study examined the contribution of prospectively measured cumulative life stress in preschool-age children on reward-related neural activation and connectivity in school-age children. METHODS: Children (N = 46) and caregivers reported children’s exposure to early life stress between birth and preschool age (mean = 4.8 years, SD = 0.80). At follow-up (mean age = 7.52 years, SD = .78), participants performed a child-friendly monetary incentive delay task during functional magnetic resonance imaging. RESULTS: Children with higher levels of cumulative early life stress, controlling for concurrent stressful life events, exhibited aberrant patterns of neural activation and connectivity in reward- and emotion-related regions (e.g., prefrontal cortex, temporal pole, culmen), depending on the presence of a potential reward and whether or not the target was hit or missed. CONCLUSIONS: Findings suggest that stress exposure during early childhood may impact neural reward processing systems earlier in development than has previously been demonstrated. Understanding how early life stress relates to alterations in reward processing could guide earlier, more mechanistic interventions. Elsevier 2021-05-15 /pmc/articles/PMC8144345/ /pubmed/34020397 http://dx.doi.org/10.1016/j.dcn.2021.100963 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Morelli, Nicholas M.
Liuzzi, Michael T.
Duong, Jacqueline B.
Kryza-Lacombe, Maria
Chad-Friedman, Emma
Villodas, Miguel T.
Dougherty, Lea R.
Wiggins, Jillian Lee
Reward-related neural correlates of early life stress in school-aged children
title Reward-related neural correlates of early life stress in school-aged children
title_full Reward-related neural correlates of early life stress in school-aged children
title_fullStr Reward-related neural correlates of early life stress in school-aged children
title_full_unstemmed Reward-related neural correlates of early life stress in school-aged children
title_short Reward-related neural correlates of early life stress in school-aged children
title_sort reward-related neural correlates of early life stress in school-aged children
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144345/
https://www.ncbi.nlm.nih.gov/pubmed/34020397
http://dx.doi.org/10.1016/j.dcn.2021.100963
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