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Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states

Sex-hormone-binding globulin (SHBG) regulates the transport and bioavailability of estradiol. The dynamics of estradiol's binding to SHBG are incompletely understood, although it is believed that estradiol binds to each monomer of SHBG dimer with identical affinity (K(d) ∼2 nM). Contrary to the...

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Detalles Bibliográficos
Autores principales:	Jasuja, Ravi, Spencer, Daniel, Jayaraj, Abhilash, Peng, Liming, Krishna, Meenakshi, Lawney, Brian, Patel, Priyank, Jayaram, Bhyravabhotla, Thayer, Kelly M., Beveridge, David L., Bhasin, Shalender
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144348/ https://www.ncbi.nlm.nih.gov/pubmed/34041454 http://dx.doi.org/10.1016/j.isci.2021.102414

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