A combined evolutionary and structural approach to disclose the primary structural determinants essential for proneurotrophins biological functions

The neurotrophins, i.e., Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin 3 (NT3) and Neurotrophin 4 (NT4), are known to play a range of crucial functions in the developing and adult peripheral and central nervous systems. Initially synthesized as precursors, i.e., p...

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Detalles Bibliográficos
Autores principales: Covaceuszach, S., Peche, L.Y., Konarev, P.V., Lamba, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144349/
https://www.ncbi.nlm.nih.gov/pubmed/34094000
http://dx.doi.org/10.1016/j.csbj.2021.05.007

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