Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer

The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following chemotherapy is only partially understood. To understand the selection of factors driving heterogeneity before and through adaptation to treatment, we profile single-cell RNA-sequencing (scRNA-seq) transcriptomes...

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Detalles Bibliográficos
Autores principales: Nath, Aritro, Cosgrove, Patrick A., Mirsafian, Hoda, Christie, Elizabeth L., Pflieger, Lance, Copeland, Benjamin, Majumdar, Sumana, Cristea, Mihaela C., Han, Ernest S., Lee, Stephen J., Wang, Edward W., Fereday, Sian, Traficante, Nadia, Salgia, Ravi, Werner, Theresa, Cohen, Adam L., Moos, Philip, Chang, Jeffrey T., Bowtell, David D. L., Bild, Andrea H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144406/
https://www.ncbi.nlm.nih.gov/pubmed/34031395
http://dx.doi.org/10.1038/s41467-021-23171-3

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