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Anti-tumor effects of an ID antagonist with no observed acquired resistance

ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation. A small-molecule, AGX51, targets ID proteins for degradation and impairs ocular neova...

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Detalles Bibliográficos
Autores principales:	Wojnarowicz, Paulina M., Escolano, Marta Garcia, Huang, Yun-Han, Desai, Bina, Chin, Yvette, Shah, Riddhi, Xu, Sijia, Yadav, Saurabh, Yaklichkin, Sergey, Ouerfelli, Ouathek, Soni, Rajesh Kumar, Philip, John, Montrose, David C., Healey, John H., Rajasekhar, Vinagolu K., Garland, William A., Ratiu, Jeremy, Zhuang, Yuan, Norton, Larry, Rosen, Neal, Hendrickson, Ronald C., Zhou, Xi Kathy, Iavarone, Antonio, Massague, Joan, Dannenberg, Andrew J., Lasorella, Anna, Benezra, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144414/ https://www.ncbi.nlm.nih.gov/pubmed/34031428 http://dx.doi.org/10.1038/s41523-021-00266-0

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