Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

Mechanical loading to the bone is known to be beneficial for bone homeostasis and for suppressing tumor-induced osteolysis in the loaded bone. However, whether loading to a weight-bearing hind limb can inhibit distant tumor growth in the brain is unknown. We examined the possibility of bone-to-brain...

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Detalles Bibliográficos
Autores principales: Fan, Yao, Zha, Rongrong, Sano, Tomohiko, Zhao, Xinyu, Liu, Shengzhi, Woollam, Mark D., Wu, Di, Sun, Xun, Li, Kexin, Egi, Motoki, Li, Fangjia, Minami, Kazumasa, Siegel, Amanda P., Horiuchi, Takashi, Liu, Jing, Agarwal, Mangilal, Sudo, Akihiro, Nakshatri, Harikrishna, Li, Bai-Yan, Yokota, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144433/
https://www.ncbi.nlm.nih.gov/pubmed/34031366
http://dx.doi.org/10.1038/s41413-021-00144-2

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