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The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives

Hepatocellular carcinoma (HCC) is the 6th most prevalent cancer and the 4th leading cause of cancer-related death worldwide. Mechanisms explaining the carcinogenesis of HCC are not clear yet. In recent years, rapid development of N(6)-methyladenosine (m6A) modification provides a fresh approach to d...

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Autores principales: Pan, Fan, Lin, Xin-Rong, Hao, Li-Ping, Chu, Xiao-Yuan, Wan, Hai-Jun, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144501/
https://www.ncbi.nlm.nih.gov/pubmed/34046411
http://dx.doi.org/10.3389/fcell.2021.674919
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author Pan, Fan
Lin, Xin-Rong
Hao, Li-Ping
Chu, Xiao-Yuan
Wan, Hai-Jun
Wang, Rui
author_facet Pan, Fan
Lin, Xin-Rong
Hao, Li-Ping
Chu, Xiao-Yuan
Wan, Hai-Jun
Wang, Rui
author_sort Pan, Fan
collection PubMed
description Hepatocellular carcinoma (HCC) is the 6th most prevalent cancer and the 4th leading cause of cancer-related death worldwide. Mechanisms explaining the carcinogenesis of HCC are not clear yet. In recent years, rapid development of N(6)-methyladenosine (m6A) modification provides a fresh approach to disclosing this mystery. As the most prevalent mRNA modification in eukaryotes, m6A modification is capable to post-transcriptionally affect RNA splicing, stability, and translation, thus participating in a variety of biological and pathological processes including cell proliferation, apoptosis, tumor invasion and metastasis. METTL3 has been recognized as a pivotal methyltransferase and essential to the performance of m6A modification. METTL3 can regulate RNA expression in a m6A-dependent manner and contribute to the carcinogenesis, tumor progression, and drug resistance of HCC. In the present review, we are going to make a clear summary of the known roles of METTL3 in HCC, and explicitly narrate the potential mechanisms for these roles.
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spelling pubmed-81445012021-05-26 The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives Pan, Fan Lin, Xin-Rong Hao, Li-Ping Chu, Xiao-Yuan Wan, Hai-Jun Wang, Rui Front Cell Dev Biol Cell and Developmental Biology Hepatocellular carcinoma (HCC) is the 6th most prevalent cancer and the 4th leading cause of cancer-related death worldwide. Mechanisms explaining the carcinogenesis of HCC are not clear yet. In recent years, rapid development of N(6)-methyladenosine (m6A) modification provides a fresh approach to disclosing this mystery. As the most prevalent mRNA modification in eukaryotes, m6A modification is capable to post-transcriptionally affect RNA splicing, stability, and translation, thus participating in a variety of biological and pathological processes including cell proliferation, apoptosis, tumor invasion and metastasis. METTL3 has been recognized as a pivotal methyltransferase and essential to the performance of m6A modification. METTL3 can regulate RNA expression in a m6A-dependent manner and contribute to the carcinogenesis, tumor progression, and drug resistance of HCC. In the present review, we are going to make a clear summary of the known roles of METTL3 in HCC, and explicitly narrate the potential mechanisms for these roles. Frontiers Media S.A. 2021-05-11 /pmc/articles/PMC8144501/ /pubmed/34046411 http://dx.doi.org/10.3389/fcell.2021.674919 Text en Copyright © 2021 Pan, Lin, Hao, Chu, Wan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Pan, Fan
Lin, Xin-Rong
Hao, Li-Ping
Chu, Xiao-Yuan
Wan, Hai-Jun
Wang, Rui
The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
title The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
title_full The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
title_fullStr The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
title_full_unstemmed The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
title_short The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
title_sort role of rna methyltransferase mettl3 in hepatocellular carcinoma: results and perspectives
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144501/
https://www.ncbi.nlm.nih.gov/pubmed/34046411
http://dx.doi.org/10.3389/fcell.2021.674919
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