CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data

Controlling off-target editing activity is one of the central challenges in making CRISPR technology accurate and applicable in medical practice. Current algorithms for analyzing off-target activity do not provide statistical quantification, are not sufficiently sensitive in separating signal from n...

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Detalles Bibliográficos
Autores principales: Amit, Ido, Iancu, Ortal, Levy-Jurgenson, Alona, Kurgan, Gavin, McNeill, Matthew S., Rettig, Garrett R., Allen, Daniel, Breier, Dor, Ben Haim, Nimrod, Wang, Yu, Anavy, Leon, Hendel, Ayal, Yakhini, Zohar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144550/
https://www.ncbi.nlm.nih.gov/pubmed/34031394
http://dx.doi.org/10.1038/s41467-021-22417-4

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