The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer

Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ABI1 presents as at least 12 transcript variants (TSVs) by mRNA alternative splicing, but it is unknown which of them is involved in CRC metastasis and pr...

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Autores principales: Zhang, Yu, Zhong, Zhaohui, Li, Mei, Chen, Jingyi, Lin, Tingru, Sun, Jie, Wang, Di, Mu, Qing, Su, Huiting, Wu, Na, Liu, Aiyu, Yu, Yimeng, Zhang, Menglei, Liu, Yulan, Guo, Jingzhu, Yu, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144562/
https://www.ncbi.nlm.nih.gov/pubmed/34031495
http://dx.doi.org/10.1038/s41598-021-90220-8
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author Zhang, Yu
Zhong, Zhaohui
Li, Mei
Chen, Jingyi
Lin, Tingru
Sun, Jie
Wang, Di
Mu, Qing
Su, Huiting
Wu, Na
Liu, Aiyu
Yu, Yimeng
Zhang, Menglei
Liu, Yulan
Guo, Jingzhu
Yu, Weidong
author_facet Zhang, Yu
Zhong, Zhaohui
Li, Mei
Chen, Jingyi
Lin, Tingru
Sun, Jie
Wang, Di
Mu, Qing
Su, Huiting
Wu, Na
Liu, Aiyu
Yu, Yimeng
Zhang, Menglei
Liu, Yulan
Guo, Jingzhu
Yu, Weidong
author_sort Zhang, Yu
collection PubMed
description Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ABI1 presents as at least 12 transcript variants (TSVs) by mRNA alternative splicing, but it is unknown which of them is involved in CRC metastasis and prognosis. Here, we firstly identified ABI1-TSV-11 as a key TSV affecting the metastasis and prognosis of left-sided colorectal cancer (LsCC) and its elevated expression is related to lymph node metastasis and shorter overall survival (OS) in LsCC by analyzing data from The Cancer Genome Atlas and TSVdb. Secondly, ABI1-TSV-11 overexpression promoted LoVo and SW480 cells adhesion and migration in vitro, and accelerated LoVo and SW480 cells lung metastasis in vivo. Finally, mechanism investigations revealed that ABI1-isoform-11 interacted with epidermal growth factor receptor pathway substrate 8 (ESP8) and regulated actin dynamics to affect LoVo and SW480 cells biological behaviors. Taken together, our data demonstrated that ABI1-TSV-11 plays an oncogenic role in LsCC, it is an independent risk factor of prognosis and may be a potential molecular marker and therapeutic target in LsCC.
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spelling pubmed-81445622021-05-26 The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer Zhang, Yu Zhong, Zhaohui Li, Mei Chen, Jingyi Lin, Tingru Sun, Jie Wang, Di Mu, Qing Su, Huiting Wu, Na Liu, Aiyu Yu, Yimeng Zhang, Menglei Liu, Yulan Guo, Jingzhu Yu, Weidong Sci Rep Article Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ABI1 presents as at least 12 transcript variants (TSVs) by mRNA alternative splicing, but it is unknown which of them is involved in CRC metastasis and prognosis. Here, we firstly identified ABI1-TSV-11 as a key TSV affecting the metastasis and prognosis of left-sided colorectal cancer (LsCC) and its elevated expression is related to lymph node metastasis and shorter overall survival (OS) in LsCC by analyzing data from The Cancer Genome Atlas and TSVdb. Secondly, ABI1-TSV-11 overexpression promoted LoVo and SW480 cells adhesion and migration in vitro, and accelerated LoVo and SW480 cells lung metastasis in vivo. Finally, mechanism investigations revealed that ABI1-isoform-11 interacted with epidermal growth factor receptor pathway substrate 8 (ESP8) and regulated actin dynamics to affect LoVo and SW480 cells biological behaviors. Taken together, our data demonstrated that ABI1-TSV-11 plays an oncogenic role in LsCC, it is an independent risk factor of prognosis and may be a potential molecular marker and therapeutic target in LsCC. Nature Publishing Group UK 2021-05-24 /pmc/articles/PMC8144562/ /pubmed/34031495 http://dx.doi.org/10.1038/s41598-021-90220-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Yu
Zhong, Zhaohui
Li, Mei
Chen, Jingyi
Lin, Tingru
Sun, Jie
Wang, Di
Mu, Qing
Su, Huiting
Wu, Na
Liu, Aiyu
Yu, Yimeng
Zhang, Menglei
Liu, Yulan
Guo, Jingzhu
Yu, Weidong
The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_full The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_fullStr The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_full_unstemmed The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_short The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer
title_sort roles and prognostic significance of abi1-tsv-11 expression in patients with left-sided colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144562/
https://www.ncbi.nlm.nih.gov/pubmed/34031495
http://dx.doi.org/10.1038/s41598-021-90220-8
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