MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway

Milk fat globule-epidermal growth factor (EGF) factor 8 (MFG-E8), as a necessary bridging molecule between apoptotic cells and phagocytic cells, has been widely studied in various organs and diseases, while the effect of MFG-E8 in osteoarthritis (OA) remains unclear. Here, we identified MFG-E8 as a...

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Detalles Bibliográficos
Autores principales: Lu, Yuheng, Liu, Liangliang, Pan, Jianying, Luo, Bingsheng, Zeng, Hua, Shao, Yan, Zhang, Hongbo, Guan, Hong, Guo, Dong, Zeng, Chun, Zhang, Rongkai, Bai, Xiaochun, Zhang, Haiyan, Cai, Daozhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144578/
https://www.ncbi.nlm.nih.gov/pubmed/34031369
http://dx.doi.org/10.1038/s41419-021-03800-x

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