Cargando…

Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway

miRNA-21 is a single-stranded non-coding RNA that is highly expressed in a variety of tumor cells. It participates in tumor cell proliferation, metabolism, metastasis, and drug resistance. Here, we tested the potential mechanism of miRNA-21 in cisplatin-resistant non-small cell lung cancer A549/DDP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Ye, Liu, Wenjun, Zhao, Qiuyu, Zhang, Ruiqi, Wang, Jianbo, Pan, Pengyu, Shang, Hai, Liu, Chunying, Wang, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144645/ https://www.ncbi.nlm.nih.gov/pubmed/34046349 http://dx.doi.org/10.3389/fonc.2021.653596

Ejemplares similares

Overcoming Basal Autophagy, Kangai Injection Enhances Cisplatin Cytotoxicity by Regulating FOXO3a-Dependent Autophagic Cell Death and Apoptosis in Human Lung Adenocarcinoma A549/DDP Cells
por: Zhou, Huan, et al.
Publicado: (2022)

Shenmai Injection Supresses Glycolysis and Enhances Cisplatin Cytotoxicity in Cisplatin-Resistant A549/DDP Cells via the AKT-mTOR-c-Myc Signaling Pathway
por: Sun, Ye, et al.
Publicado: (2020)

Effect of BRAF-mediated PI3K/Akt/mTOR pathway on biological characteristics and chemosensitivity of NSCLC A549/DDP cells
por: Ren, Bingnan, et al.
Publicado: (2021)

Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells
por: Chen, Li-Min, et al.
Publicado: (2017)

Shenqi Fuzheng Injection Reverses Cisplatin Resistance through Mitofusin-2-Mediated Cell Cycle Arrest and Apoptosis in A549/DDP Cells
por: Xiong, Ying, et al.
Publicado: (2018)

Shenmai injection enhances cisplatin-induced apoptosis through regulation of Mfn2-dependent mitochondrial dynamics in lung adenocarcinoma A549/DDP cells
por: Chen, Yushi, et al.
Publicado: (2021)

Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis
por: Feng, Feifei, et al.
Publicado: (2019)

The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells
por: Ye, Ling-Yun, et al.
Publicado: (2017)

Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells
por: Liang, Jin-xiao, et al.
Publicado: (2017)

TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling Pathway
por: Shi, Lu, et al.
Publicado: (2019)

Cytokine-Induced Killer Cells Modulates Resistance to Cisplatin in the A549/DDP Cell Line
por: Yang, Lili, et al.
Publicado: (2017)

Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death
por: Huo, Ruichao, et al.
Publicado: (2016)

Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells
por: Yang, Huahong, et al.
Publicado: (2019)

Comparative analysis of microRNA expression profiles between A549, A549/DDP and their respective exosomes
por: Qin, Xiaobing, et al.
Publicado: (2017)

NMR studies of the relationship between the changes of membrane lipids and the cisplatin-resistance of A549/DDP cells
por: Huang, Zhenhua, et al.
Publicado: (2003)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Alcohol Extract of YFXJ Decoction Reverses the Drug Resistance of Human Lung Adenocarcinoma Cell Line A549/DDP
por: Liu, Zhongliang, et al.
Publicado: (2022)

Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway
por: Ma, Zhenling, et al.
Publicado: (2021)

Treatment with 20(S)-ginsenoside Rg3 reverses multidrug resistance in A549/DDP xenograft tumors
por: Liu, Chao, et al.
Publicado: (2018)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Effect of DNA methylation inhibitor on RASSF1A genes expression in non-small cell lung cancer cell line A549 and A549DDP
por: Mengxi, Duan, et al.
Publicado: (2013)

Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells
por: Liu, Xiaoli, et al.
Publicado: (2019)

Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells
por: Appelberg, Sofia, et al.
Publicado: (2020)

Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways
por: Cao, Pikun, et al.
Publicado: (2019)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Streptococcus pneumoniae Induces Autophagy through the Inhibition of the PI3K-I/Akt/mTOR Pathway and ROS Hypergeneration in A549 Cells
por: Li, Pu, et al.
Publicado: (2015)

HIF-1α increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1α/VEGF/AKT/mTOR signaling pathway
por: Song, Shuang, et al.
Publicado: (2023)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway
por: Yan, Xianke, et al.
Publicado: (2020)

HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway
por: Shen, Guoliang, et al.
Publicado: (2022)

Reversal effect of adenovirus-mediated human interleukin 24 transfection on the cisplatin resistance of A549/DDP lung cancer cells
por: Xu, Mingju, et al.
Publicado: (2017)

Retracted: Alcohol Extract of YFXJ Decoction Reverses the Drug Resistance of Human Lung Adenocarcinoma Cell Line A549/DDP
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells
por: Pan, Chen, et al.
Publicado: (2019)

Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism
por: Li, Bo, et al.
Publicado: (2019)

HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway
por: Xu, Wen-Ning, et al.
Publicado: (2020)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

AKT shuts down the TOR network
por: Short, Ben
Publicado: (2013)

Hydroxytyrosol Alleviated Hypoxia-Mediated PC12 Cell Damage through Activating PI3K/AKT/mTOR-HIF-1α Signaling
por: Li, Xiaolin, et al.
Publicado: (2022)

VDR agonists down regulate PI3K/Akt/mTOR axis and trigger autophagy in Kaposi's sarcoma cells
por: Suares, Alejandra, et al.
Publicado: (2019)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4u28ue8eucamli669fnjuulo3a