Cargando…

Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis

PURPOSE: To compare the therapeutic outcomes between open surgical resection (OSR) and percutaneous microwave ablation (PMWA) for colorectal liver metastasis (CRLM) ≤3 cm. METHODS: In this retrospective study, 200 consecutive patients with 306 CRLMs were reviewed. Overall survival (OS), disease-free...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Qinxian, Cheng, Zhigang, Han, Zhiyu, Liu, Fangyi, Yu, Xiaoling, Tan, Xianliang, Han, Bin, Dou, Jianping, Yu, Jie, Liang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144705/
https://www.ncbi.nlm.nih.gov/pubmed/34046342
http://dx.doi.org/10.3389/fonc.2021.638165
_version_ 1783697015487594496
author Zhao, Qinxian
Cheng, Zhigang
Han, Zhiyu
Liu, Fangyi
Yu, Xiaoling
Tan, Xianliang
Han, Bin
Dou, Jianping
Yu, Jie
Liang, Ping
author_facet Zhao, Qinxian
Cheng, Zhigang
Han, Zhiyu
Liu, Fangyi
Yu, Xiaoling
Tan, Xianliang
Han, Bin
Dou, Jianping
Yu, Jie
Liang, Ping
author_sort Zhao, Qinxian
collection PubMed
description PURPOSE: To compare the therapeutic outcomes between open surgical resection (OSR) and percutaneous microwave ablation (PMWA) for colorectal liver metastasis (CRLM) ≤3 cm. METHODS: In this retrospective study, 200 consecutive patients with 306 CRLMs were reviewed. Overall survival (OS), disease-free survival (DFS), local tumour progression (LTP), intrahepatic distant recurrence, and extrahepatic metastasis were analysed to compare the therapeutic efficacy. Cox proportional hazards regression analysis was used to identify the prognostic factors for OS and DFS. Major complications and postoperative hospital stay were also assessed. RESULT: The 1-, 3-, and 5-year OS rates were 91.6%, 64.1%, and 46.3%, respectively, in the PMWA group and 89.7%, 62.4% and 44.7%, respectively, in the OSR group (P=0.839). The 1-, 3-, and 5-year DFS rates were 61.9%, 44.8%, and 41.3%, respectively, in the PMWA group and 58.1%, 24.4%, and 18.3%, respectively, in the OSR group (P =0.066). The two groups had comparable 5-year cumulative rates of intrahepatic distant recurrence (P=0.627) and extrahepatic metastasis (P=0.884). The 5-year cumulative LTP rate was lower in the OSR group than in the PMWA group (P=0.023). The rate of major complications was higher in the OSR group than in the PMWA group (P =0.025), and the length of hospital stay after treatment was shorter in the PMWA group (P<0.001). CONCLUSION: There were no significant differences in OS or DFS between the two groups. PMWA was associated with increased LTP, fewer postoperative days and fewer major complications.
format Online
Article
Text
id pubmed-8144705
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81447052021-05-26 Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis Zhao, Qinxian Cheng, Zhigang Han, Zhiyu Liu, Fangyi Yu, Xiaoling Tan, Xianliang Han, Bin Dou, Jianping Yu, Jie Liang, Ping Front Oncol Oncology PURPOSE: To compare the therapeutic outcomes between open surgical resection (OSR) and percutaneous microwave ablation (PMWA) for colorectal liver metastasis (CRLM) ≤3 cm. METHODS: In this retrospective study, 200 consecutive patients with 306 CRLMs were reviewed. Overall survival (OS), disease-free survival (DFS), local tumour progression (LTP), intrahepatic distant recurrence, and extrahepatic metastasis were analysed to compare the therapeutic efficacy. Cox proportional hazards regression analysis was used to identify the prognostic factors for OS and DFS. Major complications and postoperative hospital stay were also assessed. RESULT: The 1-, 3-, and 5-year OS rates were 91.6%, 64.1%, and 46.3%, respectively, in the PMWA group and 89.7%, 62.4% and 44.7%, respectively, in the OSR group (P=0.839). The 1-, 3-, and 5-year DFS rates were 61.9%, 44.8%, and 41.3%, respectively, in the PMWA group and 58.1%, 24.4%, and 18.3%, respectively, in the OSR group (P =0.066). The two groups had comparable 5-year cumulative rates of intrahepatic distant recurrence (P=0.627) and extrahepatic metastasis (P=0.884). The 5-year cumulative LTP rate was lower in the OSR group than in the PMWA group (P=0.023). The rate of major complications was higher in the OSR group than in the PMWA group (P =0.025), and the length of hospital stay after treatment was shorter in the PMWA group (P<0.001). CONCLUSION: There were no significant differences in OS or DFS between the two groups. PMWA was associated with increased LTP, fewer postoperative days and fewer major complications. Frontiers Media S.A. 2021-05-11 /pmc/articles/PMC8144705/ /pubmed/34046342 http://dx.doi.org/10.3389/fonc.2021.638165 Text en Copyright © 2021 Zhao, Cheng, Han, Liu, Yu, Tan, Han, Dou, Yu and Liang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhao, Qinxian
Cheng, Zhigang
Han, Zhiyu
Liu, Fangyi
Yu, Xiaoling
Tan, Xianliang
Han, Bin
Dou, Jianping
Yu, Jie
Liang, Ping
Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis
title Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis
title_full Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis
title_fullStr Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis
title_full_unstemmed Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis
title_short Percutaneous Microwave Ablation Versus Open Surgical Resection for Colorectal Cancer Liver Metastasis
title_sort percutaneous microwave ablation versus open surgical resection for colorectal cancer liver metastasis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144705/
https://www.ncbi.nlm.nih.gov/pubmed/34046342
http://dx.doi.org/10.3389/fonc.2021.638165
work_keys_str_mv AT zhaoqinxian percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT chengzhigang percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT hanzhiyu percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT liufangyi percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT yuxiaoling percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT tanxianliang percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT hanbin percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT doujianping percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT yujie percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis
AT liangping percutaneousmicrowaveablationversusopensurgicalresectionforcolorectalcancerlivermetastasis