Cargando…

A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India

BACKGROUND: Urinary tract infection (UTI) is common among children. Empiric antibiotics have to be started as early as possible or it may lead to an irreversible renal parenchymal damage and renal scarring in children. The objectives were to determine the prevalence and microbial profile of paediatr...

Descripción completa

Detalles Bibliográficos
Autores principales: Tryphena, Cherryl, Sahni, Rani Diana, John, Sushil, Jeyapaul, Shalini, George, Anne, Helan, Jasmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144762/
https://www.ncbi.nlm.nih.gov/pubmed/34123916
http://dx.doi.org/10.4103/jfmpc.jfmpc_2090_20
_version_ 1783697027841916928
author Tryphena, Cherryl
Sahni, Rani Diana
John, Sushil
Jeyapaul, Shalini
George, Anne
Helan, Jasmine
author_facet Tryphena, Cherryl
Sahni, Rani Diana
John, Sushil
Jeyapaul, Shalini
George, Anne
Helan, Jasmine
author_sort Tryphena, Cherryl
collection PubMed
description BACKGROUND: Urinary tract infection (UTI) is common among children. Empiric antibiotics have to be started as early as possible or it may lead to an irreversible renal parenchymal damage and renal scarring in children. The objectives were to determine the prevalence and microbial profile of paediatric UTI and to determine the antimicrobial susceptibility pattern. METHODOLOGY: This is a retrospective study which looked at urine cultures of children below 15 years that were sent during the study period. RESULTS: Among the total urine cultures sent only 21.2% showed significant growth of organisms. The most common organism isolated was E. coli (75.5%). E. coli was least sensitive to cefpodoxime and co-trimoxazole, whereas highly sensitive to nitrofurantoin. Of the total children who had significant growth, 46% had ESBL. DISCUSSION: The prevalence of culture-proven UTI among children was found to be 21.2%. The most common organism isolated among the study population was E. coli (75.5%) followed by Enterococcus species (19.0%) and Klebsiella species (14.5%). It was also found that E. coli was least sensitive to cefpodoxime (31.6%) and co-trimoxazole (26.3%), moderately to amoxicillin-clavulanate (52.4%), whereas highly sensitive to nitrofurantoin (82.9%). This was similar with the studies done at other secondary care hospitals, in Oman and Oddanchathram, South India. CONCLUSIONS: With the increasing resistance, cephalosporins should not be used in treating paediatric UTI, whereas nitrofurantoin can be started as an empiric antibiotic, which can later be changed according to the susceptibility pattern.
format Online
Article
Text
id pubmed-8144762
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-81447622021-06-11 A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India Tryphena, Cherryl Sahni, Rani Diana John, Sushil Jeyapaul, Shalini George, Anne Helan, Jasmine J Family Med Prim Care Original Article BACKGROUND: Urinary tract infection (UTI) is common among children. Empiric antibiotics have to be started as early as possible or it may lead to an irreversible renal parenchymal damage and renal scarring in children. The objectives were to determine the prevalence and microbial profile of paediatric UTI and to determine the antimicrobial susceptibility pattern. METHODOLOGY: This is a retrospective study which looked at urine cultures of children below 15 years that were sent during the study period. RESULTS: Among the total urine cultures sent only 21.2% showed significant growth of organisms. The most common organism isolated was E. coli (75.5%). E. coli was least sensitive to cefpodoxime and co-trimoxazole, whereas highly sensitive to nitrofurantoin. Of the total children who had significant growth, 46% had ESBL. DISCUSSION: The prevalence of culture-proven UTI among children was found to be 21.2%. The most common organism isolated among the study population was E. coli (75.5%) followed by Enterococcus species (19.0%) and Klebsiella species (14.5%). It was also found that E. coli was least sensitive to cefpodoxime (31.6%) and co-trimoxazole (26.3%), moderately to amoxicillin-clavulanate (52.4%), whereas highly sensitive to nitrofurantoin (82.9%). This was similar with the studies done at other secondary care hospitals, in Oman and Oddanchathram, South India. CONCLUSIONS: With the increasing resistance, cephalosporins should not be used in treating paediatric UTI, whereas nitrofurantoin can be started as an empiric antibiotic, which can later be changed according to the susceptibility pattern. Wolters Kluwer - Medknow 2021-04 2021-04-29 /pmc/articles/PMC8144762/ /pubmed/34123916 http://dx.doi.org/10.4103/jfmpc.jfmpc_2090_20 Text en Copyright: © 2021 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Tryphena, Cherryl
Sahni, Rani Diana
John, Sushil
Jeyapaul, Shalini
George, Anne
Helan, Jasmine
A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India
title A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India
title_full A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India
title_fullStr A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India
title_full_unstemmed A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India
title_short A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India
title_sort retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in rural vellore, south india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144762/
https://www.ncbi.nlm.nih.gov/pubmed/34123916
http://dx.doi.org/10.4103/jfmpc.jfmpc_2090_20
work_keys_str_mv AT tryphenacherryl aretrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT sahniranidiana aretrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT johnsushil aretrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT jeyapaulshalini aretrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT georgeanne aretrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT helanjasmine aretrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT tryphenacherryl retrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT sahniranidiana retrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT johnsushil retrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT jeyapaulshalini retrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT georgeanne retrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia
AT helanjasmine retrospectivestudyonthemicrobialspectrumandantibiogramofuropathogensinchildreninasecondarycarehospitalinruralvelloresouthindia