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Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care

OBJECTIVE: The aims of this study were to examine the efficacy among various vitamin D supplementation regimens on serum 25-hydroxyvitamin D (25(OH)D) concentrations and determine the minimal dose rate required to achieve sufficient serum concentrations (≥75 nmol/l) among older adults in long-term c...

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Autores principales: Robbins, Ronna N, Serra, Monica, Ranjit, Nalini, Hoelscher, Deanna M, Sweitzer, Sara J, Briley, Margaret E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144812/
https://www.ncbi.nlm.nih.gov/pubmed/33845929
http://dx.doi.org/10.1017/S1368980021001609
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author Robbins, Ronna N
Serra, Monica
Ranjit, Nalini
Hoelscher, Deanna M
Sweitzer, Sara J
Briley, Margaret E
author_facet Robbins, Ronna N
Serra, Monica
Ranjit, Nalini
Hoelscher, Deanna M
Sweitzer, Sara J
Briley, Margaret E
author_sort Robbins, Ronna N
collection PubMed
description OBJECTIVE: The aims of this study were to examine the efficacy among various vitamin D supplementation regimens on serum 25-hydroxyvitamin D (25(OH)D) concentrations and determine the minimal dose rate required to achieve sufficient serum concentrations (≥75 nmol/l) among older adults in long-term care (LTC). DESIGN: A 1-year medical history was abstracted from medical records, and a one-time blood draw to measure serum 25(OH)D concentrations was obtained. Individuals were stratified into vitamin D-supplemented and non-supplemented groups. The supplemented group was further categorised into four treatment forms: single-ingredient vitamin D(2or3), multivitamin, Ca with vitamin D or combination of the three, and by daily prescribed doses: 0–9·9, 10–19·9, 20–49·9, 50–99·9 and >100 μg/d. SETTING: Five LTC communities in Austin, Texas. PARTICIPANTS: One hundred seventy-three older (≥65 years) adults. RESULTS: Of the participants, 62% received a vitamin D supplement and 55% had insufficient (≤75 nmol/l) 25(OH)D serum concentrations. Individuals receiving single-ingredient vitamin D(2or3) supplementation received the highest daily vitamin D mean dose (72·5 μg/d), while combination of forms was the most frequent treatment (44%) with the highest mean serum concentration (108 nmol/l). All supplementation doses were successful at reaching sufficient serum concentrations, except those<20 μg/d. Using a prediction model, it was observed that 0·025 μg/d of vitamin D supplementation resulted in a 0·008 nmol/l increase in serum 25(OH)D concentrations. CONCLUSIONS: Based on the predictive equation, results suggest that supplementation of 37·5 μg/d of vitamin D(2or3) or combination of vitamin D is most likely to achieve sufficient serum 25(OH)D concentrations in older adults in LTC.
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spelling pubmed-81448122021-05-25 Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care Robbins, Ronna N Serra, Monica Ranjit, Nalini Hoelscher, Deanna M Sweitzer, Sara J Briley, Margaret E Public Health Nutr Research Paper OBJECTIVE: The aims of this study were to examine the efficacy among various vitamin D supplementation regimens on serum 25-hydroxyvitamin D (25(OH)D) concentrations and determine the minimal dose rate required to achieve sufficient serum concentrations (≥75 nmol/l) among older adults in long-term care (LTC). DESIGN: A 1-year medical history was abstracted from medical records, and a one-time blood draw to measure serum 25(OH)D concentrations was obtained. Individuals were stratified into vitamin D-supplemented and non-supplemented groups. The supplemented group was further categorised into four treatment forms: single-ingredient vitamin D(2or3), multivitamin, Ca with vitamin D or combination of the three, and by daily prescribed doses: 0–9·9, 10–19·9, 20–49·9, 50–99·9 and >100 μg/d. SETTING: Five LTC communities in Austin, Texas. PARTICIPANTS: One hundred seventy-three older (≥65 years) adults. RESULTS: Of the participants, 62% received a vitamin D supplement and 55% had insufficient (≤75 nmol/l) 25(OH)D serum concentrations. Individuals receiving single-ingredient vitamin D(2or3) supplementation received the highest daily vitamin D mean dose (72·5 μg/d), while combination of forms was the most frequent treatment (44%) with the highest mean serum concentration (108 nmol/l). All supplementation doses were successful at reaching sufficient serum concentrations, except those<20 μg/d. Using a prediction model, it was observed that 0·025 μg/d of vitamin D supplementation resulted in a 0·008 nmol/l increase in serum 25(OH)D concentrations. CONCLUSIONS: Based on the predictive equation, results suggest that supplementation of 37·5 μg/d of vitamin D(2or3) or combination of vitamin D is most likely to achieve sufficient serum 25(OH)D concentrations in older adults in LTC. Cambridge University Press 2022-01 2021-04-13 /pmc/articles/PMC8144812/ /pubmed/33845929 http://dx.doi.org/10.1017/S1368980021001609 Text en © The Authors 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Robbins, Ronna N
Serra, Monica
Ranjit, Nalini
Hoelscher, Deanna M
Sweitzer, Sara J
Briley, Margaret E
Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care
title Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care
title_full Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care
title_fullStr Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care
title_full_unstemmed Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care
title_short Efficacy of various prescribed vitamin D supplementation regimens on 25-hydroxyvitamin D serum levels in long-term care
title_sort efficacy of various prescribed vitamin d supplementation regimens on 25-hydroxyvitamin d serum levels in long-term care
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144812/
https://www.ncbi.nlm.nih.gov/pubmed/33845929
http://dx.doi.org/10.1017/S1368980021001609
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