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Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia

BACKGROUND: Intraventricular hemorrhage (IVH) is a serious complication of premature (<32 weeks) deliveries, especially in very-low-birth-weight (VLBW; <1500 g) neonates. Infants developing severe IVH are more prone to long-term developmental disabilities. Although 62%–79% of women in Saudi Ar...

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Autores principales: Al-Mouqdad, Mountasser Mohammad, Abdelrahim, Adli, Abdalgader, Ayman Tagelsir, Alyaseen, Nowf, Khalil, Thanaa Mustafa, Taha, Muhammed Yassen, Asfour, Suzan Suhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144857/
https://www.ncbi.nlm.nih.gov/pubmed/34084876
http://dx.doi.org/10.1016/j.ijpam.2019.11.005
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author Al-Mouqdad, Mountasser Mohammad
Abdelrahim, Adli
Abdalgader, Ayman Tagelsir
Alyaseen, Nowf
Khalil, Thanaa Mustafa
Taha, Muhammed Yassen
Asfour, Suzan Suhail
author_facet Al-Mouqdad, Mountasser Mohammad
Abdelrahim, Adli
Abdalgader, Ayman Tagelsir
Alyaseen, Nowf
Khalil, Thanaa Mustafa
Taha, Muhammed Yassen
Asfour, Suzan Suhail
author_sort Al-Mouqdad, Mountasser Mohammad
collection PubMed
description BACKGROUND: Intraventricular hemorrhage (IVH) is a serious complication of premature (<32 weeks) deliveries, especially in very-low-birth-weight (VLBW; <1500 g) neonates. Infants developing severe IVH are more prone to long-term developmental disabilities. Although 62%–79% of women in Saudi Arabia receive antenatal steroids, IVH incidence remains high. We analyzed the risk factors for IVH in preterm VLBW neonates in the central region of Saudi Arabia. METHODS: We included premature infants with IVH (n = 108) and gestational age- and birth weight-matched control group infants (n = 108) admitted to our neonatal intensive care unit. Cases were divided into mild (grades I and II; n = 56) and severe (grades III and IV; n = 52) IVH groups. Association of IVH with risk factors in the first week of life was investigated. RESULTS: The following risk factors were associated with severe IVH: lack of antenatal steroid administration (P < .001), pulmonary hemorrhage (P = .023), inotrope use (P = .032), neonatal hydrocortisone administration (P = .001), and patent ductus arteriosus (PDA) (P = .005). Multivariable logistic regression analysis revealed the following to be significant: lack of antenatal dexamethasone (adjusted odds ratio [aOR]: 0.219, 95% confidence interval [95% CI] 0.087–0.546), neonatal hydrocortisone administration (aOR: 3.519, 95% CI 1.204–10.281), and PDA (aOR: 2.718, 95% CI 1.024–7.210). Low hematocrit in the first 3 days of life was significantly associated with severe IVH (all P < .01). CONCLUSIONS: Failure to receive antenatal dexamethasone, PDA, hydrocortisone administration for neonatal hypotension, and low hematocrit in the first 3 days of life was associated with severe IVH in VLBW neonates. Clinicians and healthcare policy makers should consider these factors during decision-making.
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spelling pubmed-81448572021-06-02 Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia Al-Mouqdad, Mountasser Mohammad Abdelrahim, Adli Abdalgader, Ayman Tagelsir Alyaseen, Nowf Khalil, Thanaa Mustafa Taha, Muhammed Yassen Asfour, Suzan Suhail Int J Pediatr Adolesc Med Original Article BACKGROUND: Intraventricular hemorrhage (IVH) is a serious complication of premature (<32 weeks) deliveries, especially in very-low-birth-weight (VLBW; <1500 g) neonates. Infants developing severe IVH are more prone to long-term developmental disabilities. Although 62%–79% of women in Saudi Arabia receive antenatal steroids, IVH incidence remains high. We analyzed the risk factors for IVH in preterm VLBW neonates in the central region of Saudi Arabia. METHODS: We included premature infants with IVH (n = 108) and gestational age- and birth weight-matched control group infants (n = 108) admitted to our neonatal intensive care unit. Cases were divided into mild (grades I and II; n = 56) and severe (grades III and IV; n = 52) IVH groups. Association of IVH with risk factors in the first week of life was investigated. RESULTS: The following risk factors were associated with severe IVH: lack of antenatal steroid administration (P < .001), pulmonary hemorrhage (P = .023), inotrope use (P = .032), neonatal hydrocortisone administration (P = .001), and patent ductus arteriosus (PDA) (P = .005). Multivariable logistic regression analysis revealed the following to be significant: lack of antenatal dexamethasone (adjusted odds ratio [aOR]: 0.219, 95% confidence interval [95% CI] 0.087–0.546), neonatal hydrocortisone administration (aOR: 3.519, 95% CI 1.204–10.281), and PDA (aOR: 2.718, 95% CI 1.024–7.210). Low hematocrit in the first 3 days of life was significantly associated with severe IVH (all P < .01). CONCLUSIONS: Failure to receive antenatal dexamethasone, PDA, hydrocortisone administration for neonatal hypotension, and low hematocrit in the first 3 days of life was associated with severe IVH in VLBW neonates. Clinicians and healthcare policy makers should consider these factors during decision-making. King Faisal Specialist Hospital and Research Centre 2021-06 2019-11-25 /pmc/articles/PMC8144857/ /pubmed/34084876 http://dx.doi.org/10.1016/j.ijpam.2019.11.005 Text en © 2019 Publishing services provided by Elsevier B.V. on behalf of King Faisal Specialist Hospital & Research Centre (General Organization), Saudi Arabia. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Al-Mouqdad, Mountasser Mohammad
Abdelrahim, Adli
Abdalgader, Ayman Tagelsir
Alyaseen, Nowf
Khalil, Thanaa Mustafa
Taha, Muhammed Yassen
Asfour, Suzan Suhail
Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia
title Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia
title_full Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia
title_fullStr Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia
title_full_unstemmed Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia
title_short Risk factors for intraventricular hemorrhage in premature infants in the central region of Saudi Arabia
title_sort risk factors for intraventricular hemorrhage in premature infants in the central region of saudi arabia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144857/
https://www.ncbi.nlm.nih.gov/pubmed/34084876
http://dx.doi.org/10.1016/j.ijpam.2019.11.005
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