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A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

Recent studies with silver nanoparticles (AgNPs) and the history of silver metal as a broad-spectrum bactericidal and virucidal agent, places silver as one of the future biocidal candidates in the field of nanomedicine to eliminate bacteria and viruses, especially multidrug resistant ones. In this r...

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Autores principales: Misirli, Gabriel M, Sridharan, Kishore, Abrantes, Shirley M P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144915/
https://www.ncbi.nlm.nih.gov/pubmed/34104622
http://dx.doi.org/10.3762/bjnano.12.36
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author Misirli, Gabriel M
Sridharan, Kishore
Abrantes, Shirley M P
author_facet Misirli, Gabriel M
Sridharan, Kishore
Abrantes, Shirley M P
author_sort Misirli, Gabriel M
collection PubMed
description Recent studies with silver nanoparticles (AgNPs) and the history of silver metal as a broad-spectrum bactericidal and virucidal agent, places silver as one of the future biocidal candidates in the field of nanomedicine to eliminate bacteria and viruses, especially multidrug resistant ones. In this review, we have described the various morphologies of AgNPs and correlated the enhanced bactericidal activity with their prominent {111} facets. In addition to prioritizing the characterization we have also discussed the importance of quantifying AgNPs and silver ion content (Ag(+)) and their different mechanisms at the chemical, biological, pharmacological, and toxicological levels. The mechanism of action of AgNPs against various bacteria and viruses including the SARS-CoV-2 was analyzed in order to understand its effectiveness as an antimicrobial agent with therapeutic efficacy and low toxicity. Further, there is the need to characterize AgNPs and quantify the content of free Ag(+) for the implementation of new systematic studies of this promising agent in nanomedicine and in clinical practice.
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spelling pubmed-81449152021-06-07 A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization Misirli, Gabriel M Sridharan, Kishore Abrantes, Shirley M P Beilstein J Nanotechnol Review Recent studies with silver nanoparticles (AgNPs) and the history of silver metal as a broad-spectrum bactericidal and virucidal agent, places silver as one of the future biocidal candidates in the field of nanomedicine to eliminate bacteria and viruses, especially multidrug resistant ones. In this review, we have described the various morphologies of AgNPs and correlated the enhanced bactericidal activity with their prominent {111} facets. In addition to prioritizing the characterization we have also discussed the importance of quantifying AgNPs and silver ion content (Ag(+)) and their different mechanisms at the chemical, biological, pharmacological, and toxicological levels. The mechanism of action of AgNPs against various bacteria and viruses including the SARS-CoV-2 was analyzed in order to understand its effectiveness as an antimicrobial agent with therapeutic efficacy and low toxicity. Further, there is the need to characterize AgNPs and quantify the content of free Ag(+) for the implementation of new systematic studies of this promising agent in nanomedicine and in clinical practice. Beilstein-Institut 2021-05-14 /pmc/articles/PMC8144915/ /pubmed/34104622 http://dx.doi.org/10.3762/bjnano.12.36 Text en Copyright © 2021, Misirli et al. https://creativecommons.org/licenses/by/4.0/https://www.beilstein-journals.org/bjnano/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms/terms)
spellingShingle Review
Misirli, Gabriel M
Sridharan, Kishore
Abrantes, Shirley M P
A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
title A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
title_full A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
title_fullStr A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
title_full_unstemmed A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
title_short A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
title_sort review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144915/
https://www.ncbi.nlm.nih.gov/pubmed/34104622
http://dx.doi.org/10.3762/bjnano.12.36
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