In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease

SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has put scientist and pharmaceutical companies worldwide on the spot to develop novel treatment options and reliable vaccination for billions of people. To combat its associated disease COVID-19 and potentially ne...

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Autores principales: Heinen, Natalie, Klöhn, Mara, Steinmann, Eike, Pfaender, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144959/
https://www.ncbi.nlm.nih.gov/pubmed/33925255
http://dx.doi.org/10.3390/v13050792
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author Heinen, Natalie
Klöhn, Mara
Steinmann, Eike
Pfaender, Stephanie
author_facet Heinen, Natalie
Klöhn, Mara
Steinmann, Eike
Pfaender, Stephanie
author_sort Heinen, Natalie
collection PubMed
description SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has put scientist and pharmaceutical companies worldwide on the spot to develop novel treatment options and reliable vaccination for billions of people. To combat its associated disease COVID-19 and potentially newly emerging coronaviruses, numerous pre-clinical cell culture techniques have progressively been used, which allow the study of SARS-CoV-2 pathogenesis, basic replication mechanisms, and drug efficiency in the most authentic context. Hence, this review was designed to summarize and discuss currently used in vitro and ex vivo cell culture systems and will illustrate how these systems will help us to face the challenges imposed by the current SARS-CoV-2 pandemic.
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spelling pubmed-81449592021-05-26 In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease Heinen, Natalie Klöhn, Mara Steinmann, Eike Pfaender, Stephanie Viruses Review SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has put scientist and pharmaceutical companies worldwide on the spot to develop novel treatment options and reliable vaccination for billions of people. To combat its associated disease COVID-19 and potentially newly emerging coronaviruses, numerous pre-clinical cell culture techniques have progressively been used, which allow the study of SARS-CoV-2 pathogenesis, basic replication mechanisms, and drug efficiency in the most authentic context. Hence, this review was designed to summarize and discuss currently used in vitro and ex vivo cell culture systems and will illustrate how these systems will help us to face the challenges imposed by the current SARS-CoV-2 pandemic. MDPI 2021-04-28 /pmc/articles/PMC8144959/ /pubmed/33925255 http://dx.doi.org/10.3390/v13050792 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Heinen, Natalie
Klöhn, Mara
Steinmann, Eike
Pfaender, Stephanie
In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease
title In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease
title_full In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease
title_fullStr In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease
title_full_unstemmed In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease
title_short In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease
title_sort in vitro lung models and their application to study sars-cov-2 pathogenesis and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144959/
https://www.ncbi.nlm.nih.gov/pubmed/33925255
http://dx.doi.org/10.3390/v13050792
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