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Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources

Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the pr...

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Autores principales: Aničić, Neda, Gašić, Uroš, Lu, Feng, Ćirić, Ana, Ivanov, Marija, Jevtić, Bojan, Dimitrijević, Milena, Anđelković, Boban, Skorić, Marijana, Nestorović Živković, Jasmina, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Mišić, Danijela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145025/
https://www.ncbi.nlm.nih.gov/pubmed/33925239
http://dx.doi.org/10.3390/ph14050414
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author Aničić, Neda
Gašić, Uroš
Lu, Feng
Ćirić, Ana
Ivanov, Marija
Jevtić, Bojan
Dimitrijević, Milena
Anđelković, Boban
Skorić, Marijana
Nestorović Živković, Jasmina
Mao, Yingle
Liu, Jia
Tang, Chunping
Soković, Marina
Ye, Yang
Mišić, Danijela
author_facet Aničić, Neda
Gašić, Uroš
Lu, Feng
Ćirić, Ana
Ivanov, Marija
Jevtić, Bojan
Dimitrijević, Milena
Anđelković, Boban
Skorić, Marijana
Nestorović Živković, Jasmina
Mao, Yingle
Liu, Jia
Tang, Chunping
Soković, Marina
Ye, Yang
Mišić, Danijela
author_sort Aničić, Neda
collection PubMed
description Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
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spelling pubmed-81450252021-05-26 Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources Aničić, Neda Gašić, Uroš Lu, Feng Ćirić, Ana Ivanov, Marija Jevtić, Bojan Dimitrijević, Milena Anđelković, Boban Skorić, Marijana Nestorović Živković, Jasmina Mao, Yingle Liu, Jia Tang, Chunping Soković, Marina Ye, Yang Mišić, Danijela Pharmaceuticals (Basel) Article Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources—cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products. MDPI 2021-04-28 /pmc/articles/PMC8145025/ /pubmed/33925239 http://dx.doi.org/10.3390/ph14050414 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aničić, Neda
Gašić, Uroš
Lu, Feng
Ćirić, Ana
Ivanov, Marija
Jevtić, Bojan
Dimitrijević, Milena
Anđelković, Boban
Skorić, Marijana
Nestorović Živković, Jasmina
Mao, Yingle
Liu, Jia
Tang, Chunping
Soković, Marina
Ye, Yang
Mišić, Danijela
Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
title Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
title_full Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
title_fullStr Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
title_full_unstemmed Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
title_short Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
title_sort antimicrobial and immunomodulating activities of two endemic nepeta species and their major iridoids isolated from natural sources
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145025/
https://www.ncbi.nlm.nih.gov/pubmed/33925239
http://dx.doi.org/10.3390/ph14050414
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