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Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome

There are no studies on Candida colonization and micropeptides of saliva in any patient. Therefore, we studied the effects of the salivary antimicrobial peptide histatin 5 on oral fungal colonization; subjects were subdivided into Down syndrome (D) and normal (N) groups by age: N-1 and D-1, age <...

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Autores principales: Komatsu, Tomoko, Watanabe, Kiyoko, Hamada, Nobushiro, Helmerhorst, Eva, Oppenheim, Frank, Lee, Masaichi Chang-il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145106/
https://www.ncbi.nlm.nih.gov/pubmed/33925785
http://dx.doi.org/10.3390/antibiotics10050494
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author Komatsu, Tomoko
Watanabe, Kiyoko
Hamada, Nobushiro
Helmerhorst, Eva
Oppenheim, Frank
Lee, Masaichi Chang-il
author_facet Komatsu, Tomoko
Watanabe, Kiyoko
Hamada, Nobushiro
Helmerhorst, Eva
Oppenheim, Frank
Lee, Masaichi Chang-il
author_sort Komatsu, Tomoko
collection PubMed
description There are no studies on Candida colonization and micropeptides of saliva in any patient. Therefore, we studied the effects of the salivary antimicrobial peptide histatin 5 on oral fungal colonization; subjects were subdivided into Down syndrome (D) and normal (N) groups by age: N-1 and D-1, age <20 years; N-2 and D-2, age >40 years. Histatin 5 concentration in saliva was measured by enzyme-linked immunosorbent assay. Oral Candida species were identified using CHROMagar Candida. Candida colonization was significantly enhanced in the D-1 and D-2 groups compared to the N-1 and N-2 groups. There was no predominant difference in salivary histatin 5 concentration between the D-1 and N-1 groups, but it was significantly lower in the D-2 group than in the N-2 group. Only in the N-2 group was there a correlation between the concentration of histatin 5 and total protein, while no correlation was found in the other groups. In elderly patients with Down syndrome, the decrease in histatin 5 shown in this study may lead to oral Candida colony formation. Therefore, the results of this study suggest that a deficiency of the antimicrobial peptide histatin 5 could possibly induce oral Candida infection in DS.
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spelling pubmed-81451062021-05-26 Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome Komatsu, Tomoko Watanabe, Kiyoko Hamada, Nobushiro Helmerhorst, Eva Oppenheim, Frank Lee, Masaichi Chang-il Antibiotics (Basel) Article There are no studies on Candida colonization and micropeptides of saliva in any patient. Therefore, we studied the effects of the salivary antimicrobial peptide histatin 5 on oral fungal colonization; subjects were subdivided into Down syndrome (D) and normal (N) groups by age: N-1 and D-1, age <20 years; N-2 and D-2, age >40 years. Histatin 5 concentration in saliva was measured by enzyme-linked immunosorbent assay. Oral Candida species were identified using CHROMagar Candida. Candida colonization was significantly enhanced in the D-1 and D-2 groups compared to the N-1 and N-2 groups. There was no predominant difference in salivary histatin 5 concentration between the D-1 and N-1 groups, but it was significantly lower in the D-2 group than in the N-2 group. Only in the N-2 group was there a correlation between the concentration of histatin 5 and total protein, while no correlation was found in the other groups. In elderly patients with Down syndrome, the decrease in histatin 5 shown in this study may lead to oral Candida colony formation. Therefore, the results of this study suggest that a deficiency of the antimicrobial peptide histatin 5 could possibly induce oral Candida infection in DS. MDPI 2021-04-26 /pmc/articles/PMC8145106/ /pubmed/33925785 http://dx.doi.org/10.3390/antibiotics10050494 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Komatsu, Tomoko
Watanabe, Kiyoko
Hamada, Nobushiro
Helmerhorst, Eva
Oppenheim, Frank
Lee, Masaichi Chang-il
Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome
title Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome
title_full Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome
title_fullStr Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome
title_full_unstemmed Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome
title_short Association between Antimicrobial Peptide Histatin 5 Levels and Prevalence of Candida in Saliva of Patients with Down Syndrome
title_sort association between antimicrobial peptide histatin 5 levels and prevalence of candida in saliva of patients with down syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145106/
https://www.ncbi.nlm.nih.gov/pubmed/33925785
http://dx.doi.org/10.3390/antibiotics10050494
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