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Proteolytic Cleavage of Receptor Tyrosine Kinases

The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play impor...

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Detalles Bibliográficos
Autor principal: Huang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145142/
https://www.ncbi.nlm.nih.gov/pubmed/33947097
http://dx.doi.org/10.3390/biom11050660
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author Huang, Hao
author_facet Huang, Hao
author_sort Huang, Hao
collection PubMed
description The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular processes. The dysregulation of RTK signaling is related to various human diseases, including cancers. The proteolytic cleavage phenomenon has frequently been found among multiple receptor tyrosine kinases. More and more information about proteolytic cleavage in RTKs has been discovered, providing rich insight. In this review, we summarize research about different aspects of RTK cleavage, including its relation to cancer, to better elucidate this phenomenon. This review also presents proteolytic cleavage in various members of the RTKs.
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spelling pubmed-81451422021-05-26 Proteolytic Cleavage of Receptor Tyrosine Kinases Huang, Hao Biomolecules Review The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular processes. The dysregulation of RTK signaling is related to various human diseases, including cancers. The proteolytic cleavage phenomenon has frequently been found among multiple receptor tyrosine kinases. More and more information about proteolytic cleavage in RTKs has been discovered, providing rich insight. In this review, we summarize research about different aspects of RTK cleavage, including its relation to cancer, to better elucidate this phenomenon. This review also presents proteolytic cleavage in various members of the RTKs. MDPI 2021-04-29 /pmc/articles/PMC8145142/ /pubmed/33947097 http://dx.doi.org/10.3390/biom11050660 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Hao
Proteolytic Cleavage of Receptor Tyrosine Kinases
title Proteolytic Cleavage of Receptor Tyrosine Kinases
title_full Proteolytic Cleavage of Receptor Tyrosine Kinases
title_fullStr Proteolytic Cleavage of Receptor Tyrosine Kinases
title_full_unstemmed Proteolytic Cleavage of Receptor Tyrosine Kinases
title_short Proteolytic Cleavage of Receptor Tyrosine Kinases
title_sort proteolytic cleavage of receptor tyrosine kinases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145142/
https://www.ncbi.nlm.nih.gov/pubmed/33947097
http://dx.doi.org/10.3390/biom11050660
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