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National Seroprevalence of Coxiella burnetii in Chile, 2016–2017
Coxiella burnetii is an intracellular bacterium and the cause of the zoonotic infection, Q fever. National surveillance data on C. burnetii seroprevalence is currently not available for any South American country, making efforts of public health to implement strategies to mitigate infections in diff...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145303/ https://www.ncbi.nlm.nih.gov/pubmed/33924790 http://dx.doi.org/10.3390/pathogens10050531 |
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author | Tapia, Teresa Olivares, María Fernanda Stenos, John Iglesias, Rodrigo Díaz, Nora Vergara, Natalia Sotomayor, Viviana Gallegos, Doris Soares Magalhães, Ricardo J Acevedo, Johanna Araya, Pamela Graves, Stephen R Hormazabal, Juan Carlos |
author_facet | Tapia, Teresa Olivares, María Fernanda Stenos, John Iglesias, Rodrigo Díaz, Nora Vergara, Natalia Sotomayor, Viviana Gallegos, Doris Soares Magalhães, Ricardo J Acevedo, Johanna Araya, Pamela Graves, Stephen R Hormazabal, Juan Carlos |
author_sort | Tapia, Teresa |
collection | PubMed |
description | Coxiella burnetii is an intracellular bacterium and the cause of the zoonotic infection, Q fever. National surveillance data on C. burnetii seroprevalence is currently not available for any South American country, making efforts of public health to implement strategies to mitigate infections in different at-risk groups within the population extremely challenging. In the current study, we used two commercial anti-C. burnetii immunoassays to screen sera collected from a sample of the Chilean population as part of a 2016–2017 national health survey (n = 5166), nationwide and age-standardized. The seroprevalence for C. burnetii for persons ≥ 15 years was estimated to be 3.0% (95% CI 2.2–4.0), a level similar to national surveys from The Netherlands (2.4%) and USA (3.1%), but lower than Australia (5.6%). A linear increase of C. burnetii seropositivity was associated with an individual’s age, with the peak seroprevalence 5.6% (95% CI 3.6–8.6) observed in the ≥65 years’ group. C. burnetii seropositivity was significantly higher in the southern macro-zone 6.0% (95% CI 3.3–10.6) compared to metropolitan region 1.8% (95% CI 0.9–3.3), the former region being home to significant livestock industries, particularly dairy farming. These data will be useful to inform targeted strategies for the prevention of Q fever in at-risk populations in Chile. |
format | Online Article Text |
id | pubmed-8145303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81453032021-05-26 National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 Tapia, Teresa Olivares, María Fernanda Stenos, John Iglesias, Rodrigo Díaz, Nora Vergara, Natalia Sotomayor, Viviana Gallegos, Doris Soares Magalhães, Ricardo J Acevedo, Johanna Araya, Pamela Graves, Stephen R Hormazabal, Juan Carlos Pathogens Article Coxiella burnetii is an intracellular bacterium and the cause of the zoonotic infection, Q fever. National surveillance data on C. burnetii seroprevalence is currently not available for any South American country, making efforts of public health to implement strategies to mitigate infections in different at-risk groups within the population extremely challenging. In the current study, we used two commercial anti-C. burnetii immunoassays to screen sera collected from a sample of the Chilean population as part of a 2016–2017 national health survey (n = 5166), nationwide and age-standardized. The seroprevalence for C. burnetii for persons ≥ 15 years was estimated to be 3.0% (95% CI 2.2–4.0), a level similar to national surveys from The Netherlands (2.4%) and USA (3.1%), but lower than Australia (5.6%). A linear increase of C. burnetii seropositivity was associated with an individual’s age, with the peak seroprevalence 5.6% (95% CI 3.6–8.6) observed in the ≥65 years’ group. C. burnetii seropositivity was significantly higher in the southern macro-zone 6.0% (95% CI 3.3–10.6) compared to metropolitan region 1.8% (95% CI 0.9–3.3), the former region being home to significant livestock industries, particularly dairy farming. These data will be useful to inform targeted strategies for the prevention of Q fever in at-risk populations in Chile. MDPI 2021-04-28 /pmc/articles/PMC8145303/ /pubmed/33924790 http://dx.doi.org/10.3390/pathogens10050531 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tapia, Teresa Olivares, María Fernanda Stenos, John Iglesias, Rodrigo Díaz, Nora Vergara, Natalia Sotomayor, Viviana Gallegos, Doris Soares Magalhães, Ricardo J Acevedo, Johanna Araya, Pamela Graves, Stephen R Hormazabal, Juan Carlos National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 |
title | National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 |
title_full | National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 |
title_fullStr | National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 |
title_full_unstemmed | National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 |
title_short | National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 |
title_sort | national seroprevalence of coxiella burnetii in chile, 2016–2017 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145303/ https://www.ncbi.nlm.nih.gov/pubmed/33924790 http://dx.doi.org/10.3390/pathogens10050531 |
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