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National Seroprevalence of Coxiella burnetii in Chile, 2016–2017

Coxiella burnetii is an intracellular bacterium and the cause of the zoonotic infection, Q fever. National surveillance data on C. burnetii seroprevalence is currently not available for any South American country, making efforts of public health to implement strategies to mitigate infections in diff...

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Autores principales: Tapia, Teresa, Olivares, María Fernanda, Stenos, John, Iglesias, Rodrigo, Díaz, Nora, Vergara, Natalia, Sotomayor, Viviana, Gallegos, Doris, Soares Magalhães, Ricardo J, Acevedo, Johanna, Araya, Pamela, Graves, Stephen R, Hormazabal, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145303/
https://www.ncbi.nlm.nih.gov/pubmed/33924790
http://dx.doi.org/10.3390/pathogens10050531
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author Tapia, Teresa
Olivares, María Fernanda
Stenos, John
Iglesias, Rodrigo
Díaz, Nora
Vergara, Natalia
Sotomayor, Viviana
Gallegos, Doris
Soares Magalhães, Ricardo J
Acevedo, Johanna
Araya, Pamela
Graves, Stephen R
Hormazabal, Juan Carlos
author_facet Tapia, Teresa
Olivares, María Fernanda
Stenos, John
Iglesias, Rodrigo
Díaz, Nora
Vergara, Natalia
Sotomayor, Viviana
Gallegos, Doris
Soares Magalhães, Ricardo J
Acevedo, Johanna
Araya, Pamela
Graves, Stephen R
Hormazabal, Juan Carlos
author_sort Tapia, Teresa
collection PubMed
description Coxiella burnetii is an intracellular bacterium and the cause of the zoonotic infection, Q fever. National surveillance data on C. burnetii seroprevalence is currently not available for any South American country, making efforts of public health to implement strategies to mitigate infections in different at-risk groups within the population extremely challenging. In the current study, we used two commercial anti-C. burnetii immunoassays to screen sera collected from a sample of the Chilean population as part of a 2016–2017 national health survey (n = 5166), nationwide and age-standardized. The seroprevalence for C. burnetii for persons ≥ 15 years was estimated to be 3.0% (95% CI 2.2–4.0), a level similar to national surveys from The Netherlands (2.4%) and USA (3.1%), but lower than Australia (5.6%). A linear increase of C. burnetii seropositivity was associated with an individual’s age, with the peak seroprevalence 5.6% (95% CI 3.6–8.6) observed in the ≥65 years’ group. C. burnetii seropositivity was significantly higher in the southern macro-zone 6.0% (95% CI 3.3–10.6) compared to metropolitan region 1.8% (95% CI 0.9–3.3), the former region being home to significant livestock industries, particularly dairy farming. These data will be useful to inform targeted strategies for the prevention of Q fever in at-risk populations in Chile.
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spelling pubmed-81453032021-05-26 National Seroprevalence of Coxiella burnetii in Chile, 2016–2017 Tapia, Teresa Olivares, María Fernanda Stenos, John Iglesias, Rodrigo Díaz, Nora Vergara, Natalia Sotomayor, Viviana Gallegos, Doris Soares Magalhães, Ricardo J Acevedo, Johanna Araya, Pamela Graves, Stephen R Hormazabal, Juan Carlos Pathogens Article Coxiella burnetii is an intracellular bacterium and the cause of the zoonotic infection, Q fever. National surveillance data on C. burnetii seroprevalence is currently not available for any South American country, making efforts of public health to implement strategies to mitigate infections in different at-risk groups within the population extremely challenging. In the current study, we used two commercial anti-C. burnetii immunoassays to screen sera collected from a sample of the Chilean population as part of a 2016–2017 national health survey (n = 5166), nationwide and age-standardized. The seroprevalence for C. burnetii for persons ≥ 15 years was estimated to be 3.0% (95% CI 2.2–4.0), a level similar to national surveys from The Netherlands (2.4%) and USA (3.1%), but lower than Australia (5.6%). A linear increase of C. burnetii seropositivity was associated with an individual’s age, with the peak seroprevalence 5.6% (95% CI 3.6–8.6) observed in the ≥65 years’ group. C. burnetii seropositivity was significantly higher in the southern macro-zone 6.0% (95% CI 3.3–10.6) compared to metropolitan region 1.8% (95% CI 0.9–3.3), the former region being home to significant livestock industries, particularly dairy farming. These data will be useful to inform targeted strategies for the prevention of Q fever in at-risk populations in Chile. MDPI 2021-04-28 /pmc/articles/PMC8145303/ /pubmed/33924790 http://dx.doi.org/10.3390/pathogens10050531 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tapia, Teresa
Olivares, María Fernanda
Stenos, John
Iglesias, Rodrigo
Díaz, Nora
Vergara, Natalia
Sotomayor, Viviana
Gallegos, Doris
Soares Magalhães, Ricardo J
Acevedo, Johanna
Araya, Pamela
Graves, Stephen R
Hormazabal, Juan Carlos
National Seroprevalence of Coxiella burnetii in Chile, 2016–2017
title National Seroprevalence of Coxiella burnetii in Chile, 2016–2017
title_full National Seroprevalence of Coxiella burnetii in Chile, 2016–2017
title_fullStr National Seroprevalence of Coxiella burnetii in Chile, 2016–2017
title_full_unstemmed National Seroprevalence of Coxiella burnetii in Chile, 2016–2017
title_short National Seroprevalence of Coxiella burnetii in Chile, 2016–2017
title_sort national seroprevalence of coxiella burnetii in chile, 2016–2017
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145303/
https://www.ncbi.nlm.nih.gov/pubmed/33924790
http://dx.doi.org/10.3390/pathogens10050531
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