Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example

The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the concept: enhanced genetic discoveries,...

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Autores principales: Prins, Bram Peter, Leitsalu, Liis, Pärna, Katri, Fischer, Krista, Metspalu, Andres, Haller, Toomas, Snieder, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145318/
https://www.ncbi.nlm.nih.gov/pubmed/33946982
http://dx.doi.org/10.3390/jpm11050358
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author Prins, Bram Peter
Leitsalu, Liis
Pärna, Katri
Fischer, Krista
Metspalu, Andres
Haller, Toomas
Snieder, Harold
author_facet Prins, Bram Peter
Leitsalu, Liis
Pärna, Katri
Fischer, Krista
Metspalu, Andres
Haller, Toomas
Snieder, Harold
author_sort Prins, Bram Peter
collection PubMed
description The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the concept: enhanced genetic discoveries, translation into intervention strategies, and a systematic implementation in healthcare. Here we review how further genetic discoveries are improving personalized prediction and advance functional insights into the link between genetics and disease. In the second part we give our perspective on the way these advances in genomic research will transform the future of personalized prevention and medicine using Estonia as a primer.
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spelling pubmed-81453182021-05-26 Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example Prins, Bram Peter Leitsalu, Liis Pärna, Katri Fischer, Krista Metspalu, Andres Haller, Toomas Snieder, Harold J Pers Med Review The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the concept: enhanced genetic discoveries, translation into intervention strategies, and a systematic implementation in healthcare. Here we review how further genetic discoveries are improving personalized prediction and advance functional insights into the link between genetics and disease. In the second part we give our perspective on the way these advances in genomic research will transform the future of personalized prevention and medicine using Estonia as a primer. MDPI 2021-04-29 /pmc/articles/PMC8145318/ /pubmed/33946982 http://dx.doi.org/10.3390/jpm11050358 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Prins, Bram Peter
Leitsalu, Liis
Pärna, Katri
Fischer, Krista
Metspalu, Andres
Haller, Toomas
Snieder, Harold
Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
title Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
title_full Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
title_fullStr Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
title_full_unstemmed Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
title_short Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example
title_sort advances in genomic discovery and implications for personalized prevention and medicine: estonia as example
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145318/
https://www.ncbi.nlm.nih.gov/pubmed/33946982
http://dx.doi.org/10.3390/jpm11050358
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