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Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice

Engineered vaccinia virus serves as an oncolytic virus for cancer virotherapy. We evaluated the oncolytic characteristics of VGF- and O1-deleted recombinant mitogen-activated protein kinase (MAPK)-dependent vaccinia virus (MDRVV). We found that compared with viruses with the deletion of either gene...

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Detalles Bibliográficos
Autores principales:	Kurosaki, Hajime, Nakatake, Motomu, Sakamoto, Teruhisa, Kuwano, Nozomi, Yamane, Masato, Ishii, Kenta, Fujiwara, Yoshiyuki, Nakamura, Takafumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145488/ https://www.ncbi.nlm.nih.gov/pubmed/33922406 http://dx.doi.org/10.3390/cells10050985

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