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Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients

Autoimmune thyroiditis (AIT) is on the rise among the population, and is frequently associated with patients with acne vulgaris, especially females aged between 18–55 years old. The connection between the two is not fully elucidated. In this study, 236 patients diagnosed with acne in the dermatologi...

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Autores principales: Endres, Laura, Tit, Delia Mirela, Bungau, Simona, Pascalau, Nicoleta Anamaria, Maghiar Țodan, Laura, Bimbo-Szuhai, Erika, Iancu, Gabriela Mariana, Negrut, Nicoleta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145646/
https://www.ncbi.nlm.nih.gov/pubmed/33924808
http://dx.doi.org/10.3390/diagnostics11050794
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author Endres, Laura
Tit, Delia Mirela
Bungau, Simona
Pascalau, Nicoleta Anamaria
Maghiar Țodan, Laura
Bimbo-Szuhai, Erika
Iancu, Gabriela Mariana
Negrut, Nicoleta
author_facet Endres, Laura
Tit, Delia Mirela
Bungau, Simona
Pascalau, Nicoleta Anamaria
Maghiar Țodan, Laura
Bimbo-Szuhai, Erika
Iancu, Gabriela Mariana
Negrut, Nicoleta
author_sort Endres, Laura
collection PubMed
description Autoimmune thyroiditis (AIT) is on the rise among the population, and is frequently associated with patients with acne vulgaris, especially females aged between 18–55 years old. The connection between the two is not fully elucidated. In this study, 236 patients diagnosed with acne in the dermatological office of the private Pelican Hospital and in few private dermatological offices from Oradea, Romania, during January 2018–December 2020, aged between 12 and 55 years old, were endocrinologically investigated to determine AIT and its influence on the severity of the acne. The values for the thyroid antibodies and thyroid-stimulating hormone (TSH) were determined for all of the subjects. The frequency of AIT in the study group was 72% and was associated with severe acne (p < 0.001). Patients with AIT with normal or hypofunction had more frequent severe acne than those with hyperfunction (p < 0.001, p = 0.002). The TSH and anti thyroidperoxidase (TPO) values did not influence the severity of the acne (p = 0.494; p = 0.111), while the anti-TG values were associated with severe acne (p = 0.007). The risk analysis indicated that raised values of anti-TPO (2.91 times greater) correlated with high anti-thyroglobulin (TG) values (4.36 times greater) doubled the risk of developing severe acne in patients. In acne evolution, the existence of AIT involves significant modifications.
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spelling pubmed-81456462021-05-26 Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients Endres, Laura Tit, Delia Mirela Bungau, Simona Pascalau, Nicoleta Anamaria Maghiar Țodan, Laura Bimbo-Szuhai, Erika Iancu, Gabriela Mariana Negrut, Nicoleta Diagnostics (Basel) Article Autoimmune thyroiditis (AIT) is on the rise among the population, and is frequently associated with patients with acne vulgaris, especially females aged between 18–55 years old. The connection between the two is not fully elucidated. In this study, 236 patients diagnosed with acne in the dermatological office of the private Pelican Hospital and in few private dermatological offices from Oradea, Romania, during January 2018–December 2020, aged between 12 and 55 years old, were endocrinologically investigated to determine AIT and its influence on the severity of the acne. The values for the thyroid antibodies and thyroid-stimulating hormone (TSH) were determined for all of the subjects. The frequency of AIT in the study group was 72% and was associated with severe acne (p < 0.001). Patients with AIT with normal or hypofunction had more frequent severe acne than those with hyperfunction (p < 0.001, p = 0.002). The TSH and anti thyroidperoxidase (TPO) values did not influence the severity of the acne (p = 0.494; p = 0.111), while the anti-TG values were associated with severe acne (p = 0.007). The risk analysis indicated that raised values of anti-TPO (2.91 times greater) correlated with high anti-thyroglobulin (TG) values (4.36 times greater) doubled the risk of developing severe acne in patients. In acne evolution, the existence of AIT involves significant modifications. MDPI 2021-04-28 /pmc/articles/PMC8145646/ /pubmed/33924808 http://dx.doi.org/10.3390/diagnostics11050794 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Endres, Laura
Tit, Delia Mirela
Bungau, Simona
Pascalau, Nicoleta Anamaria
Maghiar Țodan, Laura
Bimbo-Szuhai, Erika
Iancu, Gabriela Mariana
Negrut, Nicoleta
Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients
title Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients
title_full Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients
title_fullStr Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients
title_full_unstemmed Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients
title_short Incidence and Clinical Implications of Autoimmune Thyroiditis in the Development of Acne in Young Patients
title_sort incidence and clinical implications of autoimmune thyroiditis in the development of acne in young patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145646/
https://www.ncbi.nlm.nih.gov/pubmed/33924808
http://dx.doi.org/10.3390/diagnostics11050794
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