The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy

Exosomes are microvesicles that can be secreted by various cells and carry a variety of contents; thus, they play multiple biological functions. For instance, the tumor-derived exosomes (TEXs) have been proven to have the effect of immunostimulatory in addition to immunosuppression, making TEXs attr...

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Detalles Bibliográficos
Autores principales: Shan, Zechen, Wang, Hongmei, Zhang, Yujuan, Min, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145657/
https://www.ncbi.nlm.nih.gov/pubmed/33922480
http://dx.doi.org/10.3390/life11050381
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author Shan, Zechen
Wang, Hongmei
Zhang, Yujuan
Min, Weiping
author_facet Shan, Zechen
Wang, Hongmei
Zhang, Yujuan
Min, Weiping
author_sort Shan, Zechen
collection PubMed
description Exosomes are microvesicles that can be secreted by various cells and carry a variety of contents; thus, they play multiple biological functions. For instance, the tumor-derived exosomes (TEXs) have been proven to have the effect of immunostimulatory in addition to immunosuppression, making TEXs attractive in clinical immunotherapy and targeted therapy for cancer patients. In addition, TEXs as biomarkers have important clinical diagnostic and prognostic value. Recently, TEXs have been recognized to play important roles in the abscopal effect (AbE), a newly discovered mechanism by which the distant tumors are effectively targeted and repressed during immunotherapy and radiotherapy. Therefore, TEXs has demonstrated great clinical potential in the diagnosis, prognosis and treatment of cancer patients in the future. This review summarizes and discusses the role of TEXs in clinical therapy and their role in AbE in recent studies.
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spelling pubmed-81456572021-05-26 The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy Shan, Zechen Wang, Hongmei Zhang, Yujuan Min, Weiping Life (Basel) Review Exosomes are microvesicles that can be secreted by various cells and carry a variety of contents; thus, they play multiple biological functions. For instance, the tumor-derived exosomes (TEXs) have been proven to have the effect of immunostimulatory in addition to immunosuppression, making TEXs attractive in clinical immunotherapy and targeted therapy for cancer patients. In addition, TEXs as biomarkers have important clinical diagnostic and prognostic value. Recently, TEXs have been recognized to play important roles in the abscopal effect (AbE), a newly discovered mechanism by which the distant tumors are effectively targeted and repressed during immunotherapy and radiotherapy. Therefore, TEXs has demonstrated great clinical potential in the diagnosis, prognosis and treatment of cancer patients in the future. This review summarizes and discusses the role of TEXs in clinical therapy and their role in AbE in recent studies. MDPI 2021-04-23 /pmc/articles/PMC8145657/ /pubmed/33922480 http://dx.doi.org/10.3390/life11050381 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shan, Zechen
Wang, Hongmei
Zhang, Yujuan
Min, Weiping
The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy
title The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy
title_full The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy
title_fullStr The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy
title_full_unstemmed The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy
title_short The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy
title_sort role of tumor-derived exosomes in the abscopal effect and immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145657/
https://www.ncbi.nlm.nih.gov/pubmed/33922480
http://dx.doi.org/10.3390/life11050381
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