Cargando…

A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer

Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by germline mutations in specific genes. Several factors...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turano, Mimmo, Cammarota, Francesca, Duraturo, Francesca, Izzo, Paola, De Rosa, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145725/ https://www.ncbi.nlm.nih.gov/pubmed/33923292 http://dx.doi.org/10.3390/membranes11050312

Ejemplares similares

The Epithelial to Mesenchymal Transition in Colorectal Cancer Progression: The Emerging Role of Succinate Dehydrogenase Alterations and Succinate Accumulation
por: Turano, Mimmo, et al.
Publicado: (2023)

Promising Colorectal Cancer Biomarkers for Precision Prevention and Therapy
por: Turano, Mimmo, et al.
Publicado: (2019)

Beta catenin and cytokine pathway dysregulation in patients with manifestations of the "PTEN hamartoma tumor syndrome"
por: Galatola, Martina, et al.
Publicado: (2012)

Characterisation of mesenchymal colon tumour-derived cells in tumourspheres as a model for colorectal cancer progression
por: Turano, Mimmo, et al.
Publicado: (2018)

Lithium chloride increases sensitivity to photon irradiation treatment in primary mesenchymal colon cancer cells
por: Cammarota, Francesca, et al.
Publicado: (2020)

Incomplete Segregation of MSH6 Frameshift Variants with Phenotype of Lynch Syndrome
por: Liccardo, Raffaella, et al.
Publicado: (2017)

Implications of Splicing Alterations in the Onset and Phenotypic Variability of a Family with Subclinical Manifestation of Peutz–Jeghers Syndrome: Bioinformatic and Molecular Evidence
por: Cerasuolo, Andrea, et al.
Publicado: (2020)

Novel variants of unknown significance in the PMS2 gene identified in patients with hereditary colon cancer
por: Liccardo, Raffaella, et al.
Publicado: (2019)

MiR-137 Targets the 3′ Untranslated Region of MSH2: Potential Implications in Lynch Syndrome-Related Colorectal Cancer
por: Liccardo, Raffaella, et al.
Publicado: (2021)

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population
por: Rodrigues, Fabíola Brasil Barbosa, et al.
Publicado: (2023)

Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer
por: Heo, Tae-Hwe, et al.
Publicado: (2016)

IL6/IL6R genetic diversity and plasma IL6 levels in bipolar disorder: An Indo-French study
por: Sundaresh, Aparna, et al.
Publicado: (2019)

Dissecting the IL‐6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R
por: Cupido, Arjen J., et al.
Publicado: (2022)

MSH2 Overexpression Due to an Unclassified Variant in 3’-Untranslated Region in a Patient with Colon Cancer
por: Liccardo, Raffaella, et al.
Publicado: (2020)

Novel MSH2 splice-site mutation in a young patient with Lynch syndrome
por: Liccardo, Raffaella, et al.
Publicado: (2018)

Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges
por: Duraturo, Francesca, et al.
Publicado: (2019)

Novel Implications in Molecular Diagnosis of Lynch Syndrome
por: Liccardo, Raffaella, et al.
Publicado: (2017)

New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment
por: Tianyu, Zhao, et al.
Publicado: (2021)

Pathogenic roles of IL-6 and IL-6 blocking therapy on rheumatoid arthritis
por: Yoshizaki, K, et al.
Publicado: (2003)

Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα
por: Cai, Zongye, et al.
Publicado: (2022)

Genetics, diagnosis and management of colorectal cancer (Review)
por: DE ROSA, MARINA, et al.
Publicado: (2015)

Germline Variants in MLH1 and ATM Genes in a Young Patient with MSI-H in a Precancerous Colonic Lesion
por: Nolano, Antonio, et al.
Publicado: (2023)

Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation
por: Chou, Chun-Chi, et al.
Publicado: (2022)

Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients’
por: Smieszek, Sandra P., et al.
Publicado: (2021)

Understanding the Role of Interleukin-6 (IL-6) in the Joint and Beyond: A Comprehensive Review of IL-6 Inhibition for the Management of Rheumatoid Arthritis
por: Favalli, Ennio G.
Publicado: (2020)

Dietary Iron Enhances Colonic Inflammation and IL-6/IL-11-Stat3 Signaling Promoting Colonic Tumor Development in Mice
por: Chua, Anita C. G., et al.
Publicado: (2013)

Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R
por: Wang, Jixiu, et al.
Publicado: (2022)

Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19
por: Garbers, Christoph, et al.
Publicado: (2021)

Investigation of Genetic Variations of IL6 and IL6R as Potential Prognostic and Pharmacogenetics Biomarkers: Implications for COVID-19 and Neuroinflammatory Disorders
por: Strafella, Claudia, et al.
Publicado: (2020)

Update on the management of systemic juvenile idiopathic arthritis and role of IL-1 and IL-6 inhibition
por: Grevich, Sriharsha, et al.
Publicado: (2017)

IL-6: A Potential Role in Cardiac Metabolic Homeostasis
por: Xu, Yitao, et al.
Publicado: (2018)

Role of IL-6 in Severe Inflammation
por: Inoue, Ken-ichiro, et al.
Publicado: (2021)

Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood–Retinal Barrier Integrity In Vitro
por: Mesquida, Marina, et al.
Publicado: (2019)

Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer
por: Bharti, Rashmi, et al.
Publicado: (2018)

Association between the expression levels of IL-6 and IL-6R in the hepatocellular carcinoma microenvironment and postoperative recurrence
por: Zhang, Mao, et al.
Publicado: (2018)

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
por: Tawara, Ken, et al.
Publicado: (2011)

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies
por: Vilotić, Aleksandra, et al.
Publicado: (2022)

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
por: Rose-John, Stefan
Publicado: (2012)

Athletic humans and horses: Comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest
por: Capomaccio, Stefano, et al.
Publicado: (2011)

Dual STAT-3 and IL-6R inhibition with stattic and tocilizumab decreases migration, invasion and proliferation of prostate cancer cells by targeting the IL-6/IL-6R/STAT-3 axis
por: Méndez-Clemente, Anibal, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_64vsrdckh6oidsf70e1jppi8in