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Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project

Background: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events...

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Autores principales: Zamarrón-Licona, Erasmo, Rodríguez-Pérez, José Manuel, Posadas-Sánchez, Rosalinda, Vargas-Alarcón, Gilberto, Baños-González, Manuel Alfonso, Borgonio-Cuadra, Verónica Marusa, Pérez-Hernández, Nonanzit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145882/
https://www.ncbi.nlm.nih.gov/pubmed/33925815
http://dx.doi.org/10.3390/diagnostics11050774
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author Zamarrón-Licona, Erasmo
Rodríguez-Pérez, José Manuel
Posadas-Sánchez, Rosalinda
Vargas-Alarcón, Gilberto
Baños-González, Manuel Alfonso
Borgonio-Cuadra, Verónica Marusa
Pérez-Hernández, Nonanzit
author_facet Zamarrón-Licona, Erasmo
Rodríguez-Pérez, José Manuel
Posadas-Sánchez, Rosalinda
Vargas-Alarcón, Gilberto
Baños-González, Manuel Alfonso
Borgonio-Cuadra, Verónica Marusa
Pérez-Hernández, Nonanzit
author_sort Zamarrón-Licona, Erasmo
collection PubMed
description Background: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events in asymptomatic individuals diagnosed with subclinical atherosclerosis (CAC > 0). In this study, our aim is to evaluate the participation of two polymorphisms of the PCSK9 gene as genetic markers for developing subclinical atherosclerosis and cardiometabolic risk factors in asymptomatic individuals. Methods: We analyzed two PCSK9 polymorphisms (rs2479409 and rs615563) in 394 individuals with subclinical atherosclerosis and 1102 healthy controls using real time- polymerase chain reaction (PCR). Results: Under various inheritance models adjusted for different confounding factors, the rs2479409 polymorphism was associated with an increased risk of developing subclinical atherosclerosis (OR = 1.53, P recessive = 0.041). Both polymorphisms were significantly associated with several cardiometabolic parameters. Conclusions: Our data suggest that rs2479409 polymorphism could be envisaged as a risk marker for subclinical atherosclerosis.
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spelling pubmed-81458822021-05-26 Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project Zamarrón-Licona, Erasmo Rodríguez-Pérez, José Manuel Posadas-Sánchez, Rosalinda Vargas-Alarcón, Gilberto Baños-González, Manuel Alfonso Borgonio-Cuadra, Verónica Marusa Pérez-Hernández, Nonanzit Diagnostics (Basel) Article Background: Coronary artery disease (CAD) is a chronic, inflammatory, and complex disease associated with vascular risk factors. Nowadays, the coronary artery calcium (CAC) is a specific marker of the presence and extent of atherosclerosis. Additionally, CAC is a predictor of future coronary events in asymptomatic individuals diagnosed with subclinical atherosclerosis (CAC > 0). In this study, our aim is to evaluate the participation of two polymorphisms of the PCSK9 gene as genetic markers for developing subclinical atherosclerosis and cardiometabolic risk factors in asymptomatic individuals. Methods: We analyzed two PCSK9 polymorphisms (rs2479409 and rs615563) in 394 individuals with subclinical atherosclerosis and 1102 healthy controls using real time- polymerase chain reaction (PCR). Results: Under various inheritance models adjusted for different confounding factors, the rs2479409 polymorphism was associated with an increased risk of developing subclinical atherosclerosis (OR = 1.53, P recessive = 0.041). Both polymorphisms were significantly associated with several cardiometabolic parameters. Conclusions: Our data suggest that rs2479409 polymorphism could be envisaged as a risk marker for subclinical atherosclerosis. MDPI 2021-04-26 /pmc/articles/PMC8145882/ /pubmed/33925815 http://dx.doi.org/10.3390/diagnostics11050774 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zamarrón-Licona, Erasmo
Rodríguez-Pérez, José Manuel
Posadas-Sánchez, Rosalinda
Vargas-Alarcón, Gilberto
Baños-González, Manuel Alfonso
Borgonio-Cuadra, Verónica Marusa
Pérez-Hernández, Nonanzit
Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
title Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
title_full Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
title_fullStr Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
title_full_unstemmed Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
title_short Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
title_sort variants of pcsk9 gene are associated with subclinical atherosclerosis and cardiometabolic parameters in mexicans. the gea project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145882/
https://www.ncbi.nlm.nih.gov/pubmed/33925815
http://dx.doi.org/10.3390/diagnostics11050774
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