Molecular Functions of WWOX Potentially Involved in Cancer Development

The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its rol...

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Detalles Bibliográficos
Autores principales: Taouis, Karim, Driouch, Keltouma, Lidereau, Rosette, Lallemand, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145924/
https://www.ncbi.nlm.nih.gov/pubmed/33946771
http://dx.doi.org/10.3390/cells10051051
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author Taouis, Karim
Driouch, Keltouma
Lidereau, Rosette
Lallemand, François
author_facet Taouis, Karim
Driouch, Keltouma
Lidereau, Rosette
Lallemand, François
author_sort Taouis, Karim
collection PubMed
description The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.
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spelling pubmed-81459242021-05-26 Molecular Functions of WWOX Potentially Involved in Cancer Development Taouis, Karim Driouch, Keltouma Lidereau, Rosette Lallemand, François Cells Review The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific. MDPI 2021-04-29 /pmc/articles/PMC8145924/ /pubmed/33946771 http://dx.doi.org/10.3390/cells10051051 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Taouis, Karim
Driouch, Keltouma
Lidereau, Rosette
Lallemand, François
Molecular Functions of WWOX Potentially Involved in Cancer Development
title Molecular Functions of WWOX Potentially Involved in Cancer Development
title_full Molecular Functions of WWOX Potentially Involved in Cancer Development
title_fullStr Molecular Functions of WWOX Potentially Involved in Cancer Development
title_full_unstemmed Molecular Functions of WWOX Potentially Involved in Cancer Development
title_short Molecular Functions of WWOX Potentially Involved in Cancer Development
title_sort molecular functions of wwox potentially involved in cancer development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145924/
https://www.ncbi.nlm.nih.gov/pubmed/33946771
http://dx.doi.org/10.3390/cells10051051
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