Cargando…

The Role of Knockout Olfactory Receptor Genes in Odor Discrimination

To date, little is known about the role of olfactory receptor (OR) genes on smell performance. Thanks to the availability of whole-genome sequencing data of 802 samples, we identified 41 knockout (KO) OR genes (i.e., carriers of Loss of Function variants) and evaluated their effect on odor discrimin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Concas, Maria Pina, Cocca, Massimiliano, Francescatto, Margherita, Battistuzzi, Thomas, Spedicati, Beatrice, Feresin, Agnese, Morgan, Anna, Gasparini, Paolo, Girotto, Giorgia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145969/ https://www.ncbi.nlm.nih.gov/pubmed/33922566 http://dx.doi.org/10.3390/genes12050631

Ejemplares similares

Natural human knockouts and Mendelian disorders: deep phenotyping in Italian isolates
por: Spedicati, Beatrice, et al.
Publicado: (2021)

Identifying missing pieces in color vision defects: a genome-wide association study in Silk Road populations
por: Nardone, Giuseppe Giovanni, et al.
Publicado: (2023)

Regulator of G-Protein Signalling 9: A New Candidate Gene for Sweet Food Liking?
por: Graham, Catherine Anna-Marie, et al.
Publicado: (2023)

Odontostomatological Traits in North-Eastern Italy’s Isolated Populations: An Epidemiological Cross-Sectional Study
por: Luppieri, Valentina, et al.
Publicado: (2023)

Sensory Capacities and Eating Behavior: Intriguing Results from a Large Cohort of Italian Individuals
por: Concas, Maria Pina, et al.
Publicado: (2022)

Whole-genome sequencing reveals new insights into age-related hearing loss: cumulative effects, pleiotropy and the role of selection
por: Vuckovic, Dragana, et al.
Publicado: (2018)

Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations
por: Cocca, Massimiliano, et al.
Publicado: (2016)

Hearing Function: Identification of New Candidate Genes Further Explaining the Complexity of This Sensory Ability
por: Concas, Maria Pina, et al.
Publicado: (2021)

Genetic Dissection of Temperament Personality Traits in Italian Isolates
por: Concas, Maria Pina, et al.
Publicado: (2021)

Impact of cultural and genetic structure on food choices along the Silk Road
por: Aneli, Serena, et al.
Publicado: (2022)

Lateral inhibition and odor discrimination in a model of the olfactory bulb
por: Arruda, Denise, et al.
Publicado: (2013)

Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning
por: Wang, Dejuan, et al.
Publicado: (2020)

Spatiotemporal Alterations in Primary Odorant Representations in Olfactory Marker Protein Knockout Mice
por: Kass, Marley D., et al.
Publicado: (2013)

Whole‐exome sequencing: Clinical characterization of pediatric and adult Italian patients affected by different forms of hereditary cardiovascular diseases
por: Lenarduzzi, Stefania, et al.
Publicado: (2023)

Neuronal pattern separation in the olfactory bulb improves odor discrimination learning
por: Gschwend, Olivier, et al.
Publicado: (2015)

Enhanced Odor Discrimination and Impaired Olfactory Memory by Spatially Controlled Switch of AMPA Receptors
por: Shimshek, Derya R, et al.
Publicado: (2005)

Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance
por: Knott, Thomas K, et al.
Publicado: (2012)

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss
por: Girotto, Giorgia, et al.
Publicado: (2019)

Puzzling Out the Genetic Architecture of Endometriosis: Whole-Exome Sequencing and Novel Candidate Gene Identification in a Deeply Clinically Characterised Cohort
por: Santin, Aurora, et al.
Publicado: (2023)

OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant–receptor interactions
por: Sharma, Anju, et al.
Publicado: (2021)

Human olfactory receptor responses to odorants
por: Mainland, Joel D, et al.
Publicado: (2015)

Ancestry-related distribution of Runs of homozygosity and functional variants in Qatari population
por: Mezzavilla, Massimo, et al.
Publicado: (2022)

An olfactory-based Brain-Computer Interface: electroencephalography changes during odor perception and discrimination
por: Morozova, Marina, et al.
Publicado: (2023)

A bird’s-eye view of Italian genomic variation through whole-genome sequencing
por: Cocca, Massimiliano, et al.
Publicado: (2019)

Engineered odorant receptors illuminate structural principles of odor discrimination
por: de March, Claire A., et al.
Publicado: (2023)

Altered Olfactory Processing of Stress-Related Body Odors and Artificial Odors in Patients with Panic Disorder
por: Wintermann, Gloria-Beatrice, et al.
Publicado: (2013)

Challenging Occam’s Razor: Dual Molecular Diagnoses Explain Entangled Clinical Pictures
por: Spedicati, Beatrice, et al.
Publicado: (2022)

Role of Axonal Odorant Receptors in Olfactory Topography
por: Lodovichi, Claudia
Publicado: (2020)

Human Olfactory Receptor Sensor for Odor Reconstitution
por: Kuroda, Shun’ichi, et al.
Publicado: (2023)

Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo
por: Jiang, Yue, et al.
Publicado: (2015)

Sniffing Fast: Paradoxical Effects on Odor Concentration Discrimination at the Levels of Olfactory Bulb Output and Behavior
por: Jordan, Rebecca, et al.
Publicado: (2018)

Olfactory threshold and odor discrimination ability in children – evaluation of a modified “Sniffin’ Sticks” test
por: Gellrich, Janine, et al.
Publicado: (2017)

Correction: Altered Olfactory Processing of Stress-Related Body Odors and Artificial Odors in Patients with Panic Disorder
por: Wintermann, Gloria-Beatrice, et al.
Publicado: (2013)

The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility
por: Abaffy, Tatjana, et al.
Publicado: (2011)

Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice
por: Akers, Katherine G, et al.
Publicado: (2011)

An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants
por: Bragado Alonso, Sara, et al.
Publicado: (2019)

Impairment of odor discrimination and identification is associated with disability progression and gray matter atrophy of the olfactory system in MS
por: Bsteh, Gabriel, et al.
Publicado: (2019)

Excitability of Neural Activity is Enhanced, but Neural Discrimination of Odors is Slightly Decreased, in the Olfactory Bulb of Fasted Mice
por: Wu, Jing, et al.
Publicado: (2020)

Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors
por: Egger, Veronica, et al.
Publicado: (2021)

The Spatiotemporal Analysis of Odorants at the Level of the Olfactory Receptor Sheet
por: Mozell, Maxwell Mark
Publicado: (1966)

Cannot write session to /tmp/vufind_sessions/sess_5kujubu2b626cdi9kffv1bgm6m