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Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System
Inquiries into the participation of short hydrogen bonds in stabilizing transition states and intermediate states in the thrombin, factor Xa, plasmin and activated protein C–catalyzed reactions revealed that specific binding of effectors at S(n), n = 1–4 and S’(n), n = 1–3 and at remote exosites eli...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146069/ https://www.ncbi.nlm.nih.gov/pubmed/33925363 http://dx.doi.org/10.3390/life11050396 |