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COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?

Coronavirus disease 2019 (COVID-19) and eosinophilic granulomatosis with polyangiitis (EGPA) share similarities in clinical, imaging findings and may present with respiratory distress. Differentiating a new-onset EGPA from COVID-19 during the current pandemic is a diagnostic challenge, particularly...

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Autores principales: Özdemir, Bahar, Erden, Abdulsamet, Güven, Serdar Can, Armagan, Berkan, Apaydin, Hakan, Karakas, Özlem, Akdag, Ahmet Gokhan, Ates, İhsan, Kucuksahin, Orhan, Omma, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146171/
https://www.ncbi.nlm.nih.gov/pubmed/34032896
http://dx.doi.org/10.1007/s00296-021-04896-2
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author Özdemir, Bahar
Erden, Abdulsamet
Güven, Serdar Can
Armagan, Berkan
Apaydin, Hakan
Karakas, Özlem
Akdag, Ahmet Gokhan
Ates, İhsan
Kucuksahin, Orhan
Omma, Ahmet
author_facet Özdemir, Bahar
Erden, Abdulsamet
Güven, Serdar Can
Armagan, Berkan
Apaydin, Hakan
Karakas, Özlem
Akdag, Ahmet Gokhan
Ates, İhsan
Kucuksahin, Orhan
Omma, Ahmet
author_sort Özdemir, Bahar
collection PubMed
description Coronavirus disease 2019 (COVID-19) and eosinophilic granulomatosis with polyangiitis (EGPA) share similarities in clinical, imaging findings and may present with respiratory distress. Differentiating a new-onset EGPA from COVID-19 during the current pandemic is a diagnostic challenge, particularly if other EGPA symptoms are overlooked. Here in this study we reviewed the literature regarding EGPA patients with COVID-19 and patients who diagnosed with EGPA or suffered an EGPA flare mimicking COVID-19. We conducted a literature survey in PUBMED database using meshed keywords “COVID-19” and “EGPA”, “COVID-19” and “eosinophilic granulomatosis with polyangiitis”, “COVID-19” and “Churg Strauss Syndrome”, to reveal previously reported cases involving EGPA patients who had COVID-19 infection, patients who suspected to have COVID-19 but eventually diagnosed with EGPA and patients with a known diagnosis of EGPA who suffered a flare but a COVID-19 infection was suspected initially. A total of 11 cases (6 literature cases, 5 cases from our clinic) were included in our study. Seven (63.6%) of the cases were defined as COVID-19 mimicker and 4 (36.4%) were EGPA with COVID-19. All of the cases in EGPA with COVID-19 group had a history of asthma. All of them had a positive PCR result and ground-glass opacities in thorax CT. In COVID-19 mimicker group, six (85.7%) patients had a history of asthma and other EGPA features that were observed were eosinophilia in 6 (85.7%). Our study provided clues regarding the EGPA/COVID-19 diagnostic challenge which may be useful in the current pandemic. Since none of the findings in COVID-19 are disease-specific, other conditions like EGPA should not be overlooked particularly in PCR negative patients and clinical, laboratory and imaging findings should be interpreted carefully. Furthermore, we did not observe poor outcomes in EGPA patients who had COVID-19.
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spelling pubmed-81461712021-05-25 COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis? Özdemir, Bahar Erden, Abdulsamet Güven, Serdar Can Armagan, Berkan Apaydin, Hakan Karakas, Özlem Akdag, Ahmet Gokhan Ates, İhsan Kucuksahin, Orhan Omma, Ahmet Rheumatol Int Case Based Review Coronavirus disease 2019 (COVID-19) and eosinophilic granulomatosis with polyangiitis (EGPA) share similarities in clinical, imaging findings and may present with respiratory distress. Differentiating a new-onset EGPA from COVID-19 during the current pandemic is a diagnostic challenge, particularly if other EGPA symptoms are overlooked. Here in this study we reviewed the literature regarding EGPA patients with COVID-19 and patients who diagnosed with EGPA or suffered an EGPA flare mimicking COVID-19. We conducted a literature survey in PUBMED database using meshed keywords “COVID-19” and “EGPA”, “COVID-19” and “eosinophilic granulomatosis with polyangiitis”, “COVID-19” and “Churg Strauss Syndrome”, to reveal previously reported cases involving EGPA patients who had COVID-19 infection, patients who suspected to have COVID-19 but eventually diagnosed with EGPA and patients with a known diagnosis of EGPA who suffered a flare but a COVID-19 infection was suspected initially. A total of 11 cases (6 literature cases, 5 cases from our clinic) were included in our study. Seven (63.6%) of the cases were defined as COVID-19 mimicker and 4 (36.4%) were EGPA with COVID-19. All of the cases in EGPA with COVID-19 group had a history of asthma. All of them had a positive PCR result and ground-glass opacities in thorax CT. In COVID-19 mimicker group, six (85.7%) patients had a history of asthma and other EGPA features that were observed were eosinophilia in 6 (85.7%). Our study provided clues regarding the EGPA/COVID-19 diagnostic challenge which may be useful in the current pandemic. Since none of the findings in COVID-19 are disease-specific, other conditions like EGPA should not be overlooked particularly in PCR negative patients and clinical, laboratory and imaging findings should be interpreted carefully. Furthermore, we did not observe poor outcomes in EGPA patients who had COVID-19. Springer Berlin Heidelberg 2021-05-25 2021 /pmc/articles/PMC8146171/ /pubmed/34032896 http://dx.doi.org/10.1007/s00296-021-04896-2 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021, corrected publication 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Case Based Review
Özdemir, Bahar
Erden, Abdulsamet
Güven, Serdar Can
Armagan, Berkan
Apaydin, Hakan
Karakas, Özlem
Akdag, Ahmet Gokhan
Ates, İhsan
Kucuksahin, Orhan
Omma, Ahmet
COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
title COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
title_full COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
title_fullStr COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
title_full_unstemmed COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
title_short COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
title_sort covid-19 and eosinophilic granulomatosis with polyangiitis or covid-19 mimicking eosinophilic granulomatosis with polyangiitis?
topic Case Based Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146171/
https://www.ncbi.nlm.nih.gov/pubmed/34032896
http://dx.doi.org/10.1007/s00296-021-04896-2
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