Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality

Single domain antibodies (sdAbs) have proven to be valuable probes for molecular imaging. In order to produce such probes, one strategy is the functionalization of the reactive amine side chain of lysines with a chelator, resulting in a mixture of compounds with a different degree of conjugation. In...

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Detalles Bibliográficos
Autores principales: Baudhuin, Henri, Puttemans, Janik, Hanssens, Heleen, Vanwolleghem, Philippe, Hernot, Sophie, Raes, Geert, Xavier, Catarina, Lahoutte, Tony, Debie, Pieterjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146233/
https://www.ncbi.nlm.nih.gov/pubmed/33923088
http://dx.doi.org/10.3390/ph14050407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146233/
https://www.ncbi.nlm.nih.gov/pubmed/33923088
http://dx.doi.org/10.3390/ph14050407

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