Cargando…

Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality

Single domain antibodies (sdAbs) have proven to be valuable probes for molecular imaging. In order to produce such probes, one strategy is the functionalization of the reactive amine side chain of lysines with a chelator, resulting in a mixture of compounds with a different degree of conjugation. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baudhuin, Henri, Puttemans, Janik, Hanssens, Heleen, Vanwolleghem, Philippe, Hernot, Sophie, Raes, Geert, Xavier, Catarina, Lahoutte, Tony, Debie, Pieterjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146233/ https://www.ncbi.nlm.nih.gov/pubmed/33923088 http://dx.doi.org/10.3390/ph14050407

Ejemplares similares

(68)Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers
por: Baudhuin, Henri, et al.
Publicado: (2021)

Selection of human single domain antibodies (sdAb) against thymidine kinase 1 and their incorporation into sdAb-Fc antibody constructs for potential use in cancer therapy
por: Velazquez, Edwin J., et al.
Publicado: (2022)

Phase I Study of [(68)Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)
por: Gondry, Odrade, et al.
Publicado: (2023)

Joining the in vitro immunization of alpaca lymphocytes and phage display: rapid and cost effective pipeline for sdAb synthesis
por: Comor, Lubos, et al.
Publicado: (2017)

Shortened Hinge Design of Fab x sdAb-Fc Bispecific Antibodies Enhances Redirected T-Cell Killing of Tumor Cells
por: Huang, Shuyu, et al.
Publicado: (2022)

Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making
por: Debie, Pieterjan, et al.
Publicado: (2019)

Characterization of Asia 1 sdAb from Camels Bactrianus (C. bactrianus) and Conjugation with Quantum Dots for Imaging FMDV in BHK-21 Cells
por: Yin, Shuanghui, et al.
Publicado: (2013)

Preclinical Targeted α- and β(−)-Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies
por: Puttemans, Janik, et al.
Publicado: (2020)

The Road to Personalized Myeloma Medicine: Patient-specific Single-domain Antibodies for Anti-idiotypic Radionuclide Therapy
por: Puttemans, Janik, et al.
Publicado: (2022)

Targeted Nanobody-Based Molecular Tracers for Nuclear Imaging and Image-Guided Surgery
por: Debie, Pieterjan, et al.
Publicado: (2019)

The Design and Preclinical Evaluation of a Single-Label Bimodal Nanobody Tracer for Image-Guided Surgery
por: Debie, Pieterjan, et al.
Publicado: (2021)

Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases
por: Puttemans, Janik, et al.
Publicado: (2019)

Improved Detection of Molecular Markers of Atherosclerotic Plaques Using Sub-Millimeter PET Imaging
por: Bridoux, Jessica, et al.
Publicado: (2020)

Contribution of Intrinsic Fluorescence to the Design of a New 3D-Printed Implant for Releasing SDABS
por: Nicolas, Alexandre, et al.
Publicado: (2020)

Targeted alpha therapy using short-lived alpha-particles and the promise of nanobodies as targeting vehicle
por: Dekempeneer, Yana, et al.
Publicado: (2016)

AB118. Effect of MOTILIPERM in cisplatin administered SD rats
por: Soni, Kiran Kumar, et al.
Publicado: (2016)

Anti-Human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation
por: Bridoux, Jessica, et al.
Publicado: (2020)

Dendrimer-decorated nanogels: Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma
por: Li, Xin, et al.
Publicado: (2021)

A Simple and Sensitive Method to Quantify Biodegradable Nanoparticle Biodistribution using Europium Chelates
por: Crawford, Lindsey, et al.
Publicado: (2015)

Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using a Fluorescently Labelled Anti-CEA Nanobody Probe: A Preclinical Study
por: van Manen, Labrinus, et al.
Publicado: (2023)

Ab Initio Coordination Chemistry for Nickel Chelation Motifs
por: Jesu Jaya Sudan, R., et al.
Publicado: (2015)

Gene sdaB Is Involved in the Nematocidal Activity of Enterobacter ludwigii AA4 Against the Pine Wood Nematode Bursaphelenchus xylophilus
por: Zhao, Yu, et al.
Publicado: (2022)

Influence of DOTA Chelators on Radiochemical Purity and Biodistribution of (177)Lu- and (90)Y-Rituximab in Xenografted Mice
por: Karczmarczyk, Urszula, et al.
Publicado: (2018)

Theranostics in immuno-oncology using nanobody derivatives
por: Lecocq, Quentin, et al.
Publicado: (2019)

Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer.
por: Duska, L. R., et al.
Publicado: (1997)

Digital gene expression profiling analysis of duodenum transcriptomes in SD rats administered ferrous sulfate or ferrous glycine chelate by gavage
por: Zhuo, Zhao, et al.
Publicado: (2016)

CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma
por: De Veirman, Kim, et al.
Publicado: (2021)

Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer
por: Lecocq, Q., et al.
Publicado: (2021)

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of (99m)Tc-labeled anti-EGFR affibody molecules
por: Oroujeni, Maryam, et al.
Publicado: (2018)

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha
por: De Vlaminck, Karen, et al.
Publicado: (2021)

In Vivo Biodistribution and Anti-Tumor Efficacy Evaluation of Doxorubicin and Paclitaxel-Loaded Pluronic Micelles Decorated with c(RGDyK) Peptide
por: Chen, Yanzuo, et al.
Publicado: (2016)

Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of (68)Ga-Labeled Tracers
por: Dahlsson Leitao, Charles, et al.
Publicado: (2019)

Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies
por: Silva Lima, Beatriz, et al.
Publicado: (2018)

Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy
por: Li, Xu-Jing, et al.
Publicado: (2019)

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans
por: Thorneloe, Kevin S., et al.
Publicado: (2019)

The Practice of SA-SD
por: Fisher, S
Publicado: (1989)

The practice of SA-SD
por: Fisher, S
Publicado: (1989)

In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment?
por: Truzzi, Eleonora, et al.
Publicado: (2020)

Ab Initio Insight into the Interaction of Metal-Decorated Fluorinated Carbon Fullerenes with Anti-COVID Drugs
por: Katin, Konstantin P., et al.
Publicado: (2022)

Nano-MgO/AB decorated separator to suppress shuttle effect of lithium–sulfur battery
por: Sun, Wenhao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tqu15fsnl6no03cn89gqs8heek