CRISPR Interference Efficiently Silences Latent and Lytic Viral Genes in Kaposi’s Sarcoma-Associated Herpesvirus-Infected Cells

Uncovering viral gene functions requires the modulation of gene expression through overexpression or loss-of-function. CRISPR interference (CRISPRi), a modification of the CRISPR-Cas9 gene editing technology, allows specific and efficient transcriptional silencing without genetic ablation. CRISPRi h...

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Detalles Bibliográficos
Autores principales: Brackett, Kevin, Mungale, Ameera, Lopez-Isidro, Mary, Proctor, Duncan A., Najarro, Guillermo, Arias, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146339/
https://www.ncbi.nlm.nih.gov/pubmed/33924938
http://dx.doi.org/10.3390/v13050783

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